Invest. Ophthalmol. Vis. Sci ;54(9): doi: /iovs Figure Legend:

Slides:

Advertisements

Similar presentations

Date of download: 6/3/2016 The Association for Research in Vision and Ophthalmology Copyright © All rights reserved. From: Amyloid-β Deposits Lead.

Advertisements

Date of download: 6/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Induction of Rapid and Highly Efficient Expression.

Date of download: 7/7/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Up-regulation of Brain-Derived Neurotrophic Factor.

Invest. Ophthalmol. Vis. Sci ;47(1): doi: /iovs Figure Legend:

From: Increased Choroidal Neovascularization following Laser Induction in Mice Lacking Lysyl Oxidase-like 1 Invest. Ophthalmol. Vis. Sci ;49(6):

Invest. Ophthalmol. Vis. Sci ;54(14):ORSF68-ORSF80. doi: /iovs

From: Postnatal Gene Expression in the Normal Mouse Cornea by SAGE

From: Blocking Endothelin-B Receptors Rescues Retinal Ganglion Cells from Optic Nerve Injury through Suppression of Neuroinflammation Invest. Ophthalmol.

Association of Whirlin with Cav1

Invest. Ophthalmol. Vis. Sci ;48(1):1-10. doi: /iovs Figure Legend:

From: CXCL10 Is Required to Maintain T-Cell Populations and to Control Parasite Replication during Chronic Ocular Toxoplasmosis Invest. Ophthalmol. Vis.

From: Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content Invest. Ophthalmol. Vis. Sci ;57(7):

From: Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye Invest. Ophthalmol.

From: The Use of Autologous Serum in the Development of Corneal and Oral Epithelial Equivalents in Patients with Stevens-Johnson Syndrome Invest. Ophthalmol.

From: Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre Invest. Ophthalmol. Vis. Sci ;47(11):

From: Lentiviral Vector-Mediated PAX6 Overexpression Promotes Growth and Inhibits Apoptosis of Human Retinoblastoma Cells Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;52(5): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;56(1): doi: /iovs Figure Legend:

From: Preservation of Retina Ganglion Cell Function by Morphine in a Chronic Ocular-Hypertensive Rat Model Invest. Ophthalmol. Vis. Sci ;53(7):

From: Klf4 Regulates the Expression of Slurp1, Which Functions as an Immunomodulatory Peptide in the Mouse Cornea Invest. Ophthalmol. Vis. Sci ;53(13):

From: Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In Vivo Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;58(2): doi: /iovs Figure Legend:

From: The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms Trans. Vis. Sci. Tech ;1(3):2.

From: Elevated Expression of O-GlcNAc–Modified Proteins and O-GlcNAc Transferase in Corneas of Diabetic Goto-Kakizaki Rats Invest. Ophthalmol. Vis. Sci..

From: Efficient Gene Transfer into Retinal Cells Using Adenoviral Vectors: Dependence on Receptor Expression Invest. Ophthalmol. Vis. Sci ;45(6):

From: Inflammatory Mediators Induced by Amyloid-Beta in the Retina and RPE In Vivo: Implications for Inflammasome Activation in Age-Related Macular Degeneration.

From: Deficiency of SHP-1 Protein-Tyrosine Phosphatase in “Viable Motheaten” Mice Results in Retinal Degeneration Invest. Ophthalmol. Vis. Sci ;47(3):

From: Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis.

From: Retina-Specific Protein Fascin 2 Is an Actin Cross-linker Associated with Actin Bundles in Photoreceptor Inner Segments and Calycal Processes Invest.

From: Retinal Stem Cells Transplanted into Models of Late Stages of Retinitis Pigmentosa Preferentially Adopt a Glial or a Retinal Ganglion Cell Fate Invest.

From: Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy Invest. Ophthalmol. Vis. Sci ;58(1):

From: Blocking Endothelin-B Receptors Rescues Retinal Ganglion Cells from Optic Nerve Injury through Suppression of Neuroinflammation Invest. Ophthalmol.

From: Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination Invest. Ophthalmol. Vis. Sci ;57(4):

From: Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells Invest. Ophthalmol. Vis.

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ with Exposure to Hydrostatic Pressure Invest. Ophthalmol. Vis.

From: Otago Glaucoma Surgery Outcome Study: Tissue Matrix Breakdown by Apoptotic Cells in Capsules Surrounding Molteno Implants Invest. Ophthalmol. Vis.

From: Engraftment of Adult Neural Progenitor Cells Transplanted to Rat Retina Injured by Transient Ischemia Invest. Ophthalmol. Vis. Sci ;44(7):

From: An Experimental Protocol of the Model to Quantify Traction Applied to the Retina by Vitreous Cutters Invest. Ophthalmol. Vis. Sci ;51(8):

From: Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate Trans. Vis. Sci. Tech ;6(3):4.

From: Experimental Glaucoma and Optic Nerve Transection Induce Simultaneous Upregulation of Proapoptotic and Prosurvival Genes Invest. Ophthalmol. Vis.

From: A Frameshift Mutation in RPGR Exon ORF15 Causes Photoreceptor Degeneration and Inner Retina Remodeling in a Model of X-Linked Retinitis Pigmentosa.

From: Reduced Retina Microglial Activation and Improved Optic Nerve Integrity with Minocycline Treatment in the DBA/2J Mouse Model of Glaucoma Invest.

From: Noninvasive and Simultaneous Imaging of Layer-Specific Retinal Functional Adaptation by Manganese-Enhanced MRI Invest. Ophthalmol. Vis. Sci ;47(6):

From: Efficacy and Safety of Human Retinal Progenitor Cells

From: In Vivo Imaging of Microscopic Structures in the Rat Retina

From: Adenovirus Type 37 Keratitis in the C57BL/6J Mouse

Invest. Ophthalmol. Vis. Sci ;50(10): doi: /iovs Figure Legend:

From: Cfh Genotype Interacts With Dietary Glycemic Index to Modulate Age-Related Macular Degeneration-Like Features in Mice Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;57(6): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;48(2): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;46(4): doi: /iovs Figure Legend:

From: Neural Stem Cells Derived by Small Molecules Preserve Vision

Invest. Ophthalmol. Vis. Sci ;58(2): doi: /iovs Figure Legend:

From: Arrested Foveal Development in Preterm Eyes: Thickening of the Outer Nuclear Layer and Structural Redistribution Within the Fovea Invest. Ophthalmol.

From: GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy Trans. Vis. Sci. Tech ;5(3):1.

From: GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy Trans. Vis. Sci. Tech ;5(3):1.

From: Diffusion Tensor Imaging Detected Optic Nerve Injury Correlates with Decreased Compound Action Potentials after Murine Retinal Ischemia Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;44(2): doi: /iovs Figure Legend:

From: Activation of the Alternative Complement Pathway in Vitreous is Controlled by Genetics in Age-Related Macular Degeneration Invest. Ophthalmol. Vis.

From: AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo

From: Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide Invest. Ophthalmol. Vis. Sci ;57(2):

From: Sonic Hedgehog Expression and Role in Healing Corneal Epithelium

From: Stretch to See: Lateral Tension Strongly Determines Cell Survival in Long-Term Cultures of Adult Porcine Retina Invest. Ophthalmol. Vis. Sci ;54(3):

From: Cellular Reorganization in the Human Retina during Normal Aging

Invest. Ophthalmol. Vis. Sci ;55(7): doi: /iovs Figure Legend:

Molecular Therapy - Methods & Clinical Development

Volume 4, Issue 6, Pages (December 2001)

Volume 3, Issue 4, Pages (April 2001)

Molecular Therapy - Methods & Clinical Development

Fig. 8. Electron micrographs taken from 8-week glaucoma retina

Presentation transcript:

From: Subretinal Gene Therapy of Mice With Bardet-Biedl Syndrome Type 1 Invest. Ophthalmol. Vis. Sci.. 2013;54(9):6118-6132. doi:10.1167/iovs.13-11673 Figure Legend: Expression of FLAG-BBS1 in photoreceptor cells. (A) Wild-type retina was transduced with the AAV-FLAG-Bbs1 (without AAV-GFP) and labeled with anti-FLAG antibody. Animals received subretinal injection of AAV-FLAG-Bbs1 vector at 1 month of age and were killed 2 weeks after injection. Left: Anti-FLAG immunofluorescence is seen in the retina which was over the injection site. Note the extensive labeling of the FLAG fusion protein in the outer plexiform layer, the inner segments, and to a lesser extent the outer nuclear layer. Right: A field from the same retina remote from the injection site. Scale bar: 50 μm. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; IS/OS, inner and outer segments. (B) Localization of native BBS1 protein. Left: An area of retina from a 6-week-old WT mouse that had received a subretinal injection of AAV-FLAG-Bbs1 2 weeks before. This section was stained with anti-BBS1 antibody (not anti-FLAG antibody). Right: A different section of the same retina remote from the injection site (i.e., not exposed to the vector) labeled with anti-BBS1 antibody. The anti-BBS1 antibody is labeled with Alexa Fluor 488. The amount of immunoreactive BBS1 protein in the injected area is much greater than in the uninjected area. BBS1 protein can be detected without the anti-FLAG stain; however, this antibody does not bind as avidly as the anti-FLAG antibody. Date of download: 10/20/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.