Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology Dermatology 2016;232:534-540 - DOI:10.1159/000449526 Fig.

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Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology Dermatology 2016;232:534-540 - DOI:10.1159/000449526 Fig. 1. Pathogen-derived signals activate the NLRP3 inflammasome, activating caspase-1 and stimulating the formation of IL-1β from its precursor. In cryopyrin-associated periodic syndrome, a mutated domain of NLRP3 leads to autoactivation of the same inflammatory cascade. © 2016 S. Karger AG, Basel

Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology Dermatology 2016;232:534-540 - DOI:10.1159/000449526 Fig. 2. Urticarial eruption seen in CAPS. © 2016 S. Karger AG, Basel