Disseminated Cryptococcus neoformans infection and Crohn's disease in an immunocompetent patient Guido Sciaudone, Gianluca Pellino, Ilaria Guadagni,

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Presentation transcript:

Disseminated Cryptococcus neoformans infection and Crohn's disease in an immunocompetent patient Guido Sciaudone, Gianluca Pellino, Ilaria Guadagni, Anna Somma, Francesco P. D'Armiento, Francesco Selvaggi Journal of Crohn's and Colitis Volume 5, Issue 1, Pages 60-63 (February 2011) DOI: 10.1016/j.crohns.2010.08.003 Copyright © 2010 European Crohn's and Colitis Organisation Terms and Conditions

Figure 1 Ileal resection specimen: after opening it ulcerations involving the entire wall are observed. Journal of Crohn's and Colitis 2011 5, 60-63DOI: (10.1016/j.crohns.2010.08.003) Copyright © 2010 European Crohn's and Colitis Organisation Terms and Conditions

Figure 2 CT-scan showing parenchymal thickening in the apical segment of the left lung inferior lobe, with eccentric calcification, hilar nodular lymph node enlargement with bilateral microcalcifications. Journal of Crohn's and Colitis 2011 5, 60-63DOI: (10.1016/j.crohns.2010.08.003) Copyright © 2010 European Crohn's and Colitis Organisation Terms and Conditions

Figure 3 A) Intestinal mucosa with ulceration, intense chronic inflammation, hystiocytic activation and granulomas. B) Lymph node showing epithelioid granulomas, with giant cells (hematoxylin eosin stain). C) PAS reaction: spheroidal PAS-positive forms inside a giant cell. The arrow indicates a PAS-positive body with flare effect. D-E-F) PAS reaction: intra- and extra-citoplasmatic spheroidal PAS-positive bodies. Journal of Crohn's and Colitis 2011 5, 60-63DOI: (10.1016/j.crohns.2010.08.003) Copyright © 2010 European Crohn's and Colitis Organisation Terms and Conditions