health and life sciences Driving innovation in health and life sciences Dr Ian Campbell Director, Health and Life Sciences @IanWCampbell 15 minutes including questions Ask who has heard of Innovate UK Ask who has had Innovate UK funding

We can’t stop thinking about the future Innovate UK – the UK’s innovation agency We work with people, companies and partner organisations to find and drive the science and technology innovations that will grow the UK economy - delivering productivity, new jobs and exports. Our aim at Innovate UK is to keep the UK globally competitive in the race for future prosperity. We can’t stop thinking about the future Innovate UK’s mission – growth, productivity, jobs, exports.

11,000 projects 70,000 jobs created And a return on investment of up to £7.30 for every £1 invested. Cross cutting nature within Innovate UK From health and life sciences themes Across into high value manufacturing themes.

Sectors approach to supporting businesses Emerging and Enabling Health and Life Sciences Infrastructure Systems Manufacturing Materials Open Programme We have simplified our offering into four sectors, of which health and life sciences is one, and an open programme which funds the best innovation regardless of the sector it comes from. Each of these sectors has broad-themed competitions. You can find out latest range of competitions on our website – innovateuk.org Our competitions schedule includes programmes run with partners – more details on our webpage

Economic / societal challenges Health and Life Sciences Economic / societal challenges Market potential Mechanisms Global population growing by 2bn to 9.7bn by 2050 50% more food needed by 2030 Healthcare costs rising > GDP Prevalence of chronic illness and diet related disease increasing Sector Market Year Pharmaceuticals $1.7tn 2025 Healthcare IT $202bn Medical technology $583bn Food (retail) $4.0tn 2016 Agriculture $2.4tn CR&D competitions Catapults and Agri Centres Biomedical Catalyst AgriTech Catalyst SBRI Knowledge Transfer Partnerships Priority themes Partnerships Place BEIS, DH, OLS, DIT, Defra, DfID Devolved Administrations Research Councils ABPI, BioIndustry Association British In Vitro Diagnostics Association Agricultural Levy Boards Precision Medicine Medicines Discovery Advanced Therapies Agricultural Productivity Food Quality Health and Life Sciences supports businesses across UK - map shows locations of sector funded project partners

Partnerships in health and life sciences Innovate UK does not work alone These are the many partners and co-funders that my team work with on a daily basis to deliver our programmes supporting UK businesses. From working together with the research councils to drive the best science through to commericalisation To working with government departments and business support organisations in the devolved nations to deliver some of the examples I will talk about today.

Supporting health and life science businesses around the UK Heat map showing locations of Innovate UK project partners in the health and life science sector This heat map shows the locations of project partners – researchers and businesses – that we have supported in the health and life science area. There are concentrations in the big cities where businesses, universities and hospitals are based. But there are also hot spots in rural areas with an agriculture focus. Key message here – keep applying and seek support in raising the quality of applications to help with getting above the funding threshold.

Innovate UK in the East of England Total Innovate UK grant and unique applicants 2010/11 – 2016/17 Over £231 million to 2000 business innovation projects* GCGP £159m 1,228 South East £71m 580 Hertfordshire £44m 436 New Anglia £18m 286 *LEP areas overlap, affects totals. Not the only measure of innovation activity All Innovate UK grants inc. large projects 2009 - Aug 2016

Innovate UK in the East of England Beattie Passive Scottow Enterprise Zone Processors & Growers Research Organisation Peterborough Cambridge Nanotherm Haverhill Sphere Fluidics Babraham Research Campus, Cambridge Revolve Technologies Brentwood Puridify Stevenage BioScience Catalyst All Innovate UK grants inc. large projects 2009 - Aug 2016

The government’s Industrial Strategy sets out to do just this. Investing in science, research & innovation Upgrading infrastructure Improving procurement Delivering affordable energy & clean growth Driving growth across the whole country Developing skills Supporting businesses to start & grow Encouraging trade & inward investment Cultivating world-leading sectors Creating the right local institutions Innovation doesn't just happen – it takes strategic coordination between business, government, researchers in academia and private sector investors. The government’s Industrial Strategy sets out to do just this. Innovation weaves throughout the strategy It is clearly a big focus through pillar number 1 – science, research and innovation But also through skills, growth across the whole country, supporting businesses to start and grow, trade and inward investment, creating the right local institutions (like our Catapult network) and making the UK the best place in the world to innovate in different industries Areas relevant to AMR – most of them!

Industrial Strategy Challenge Fund Investing in science, research and innovation We must become a more innovative economy and do more to commercialise our world leading science base to drive growth across the UK Industrial Strategy Challenge Fund Industry-led and powered by multi-disciplinary research and business academic collaboration Develop UK industries that are fit for the future, driving progress in technologies where the UK can become a world-leader in research and commercialisation Pillar 1 of the Industrial Strategy has seen a lot of interest since the Prime Minister’s announcement of the new Industrial Strategy Challenge Fund The Chancellor announced £4.7 billion for this parliament for this Fund, reaching £2 billion a year in funding. It will run across Innovate UK and across the Research Councils - through the new UK Research and Innovation structure set to launch in a year’s time. This really is the future of innovation – industry-led and powered by multi-disciplinary research and business academic collaboration. The Fund will bridge research, translation and business. And it will be challenge-focused – bringing sectors together to focus on the big problems that we can better solve by working together, combining science and business expertise.

Industrial Strategy Challenge Fund Medicines manufacturing technologies Robots for a safer world 6 challenges have been announced within the Industrial Strategy Challenge Fund so far – shown here on this slide. Accelerating patient access to new drugs and treatments through developing brand new medicine manufacturing technologies Developing cutting-edge artificial intelligence and robotics systems that will operate in extreme and hazardous environments Development, design and manufacture of batteries that will power the next generation of electric vehicles Developing the next generation of AI and control systems need to ensure the UK is at the forefront of the driverless cars revolution Developing the next generation of affordable light-weight composite materials for aerospace, automotive and other advanced manufacturing sectors New satellite test facility supporting new launch technologies and the manufacturing and testing capabilities that will allow the UK to construct future satellites and deliver payloads into orbit And to hit the ground running, we have funded 35 projects with £10 million in a first wave – making the most of high quality projects that we haven’t been able to fund from our existing budget. Most relevant challenge so far is medicines manufacturing technology – say here what you can within purdah… Batteries for clean and flexible energy storage Self-driving vehicles Manufacturing and materials of the future Satellites and space technology

£197m Medicines manufacturing technologies over 4 years The medicines manufacturing challenge seeks to develop technologies for the manufacture of medicines that will speed up patient access to new drugs and treatments. This will build on the exporting strengths of the UK’s biopharmaceutical sector. Delivering new medicines to patients takes time, and we need to speed this up. Here we are talking about traditional medicines but also biologics, cell and gene therapies, and vaccines. £197 million has been announced for this challenge across the next 4 years. First stages are [Ian to add verbal comments he is comfortable saying]. Developing first-of-a-kind technologies for the manufacture of medicines that will speed up patient access to new drugs and treatments, building on the exporting strengths of the UK’s biopharmaceutical sector

ISCF: Digital Health Technology Catalyst AIM: to speed up the development of new digital solutions to healthcare challenges and grow the industry. Projects must focus on the feasibility or development of digital health or digitally-enabled medical technologies. These must have the potential to achieve one or more of the following: improve patient outcomes transform healthcare delivery enable more efficient delivery of healthcare Technologies may be designed to be used in both clinical/ non-clinical everyday settings. Digital health is evolving at a rapid pace and this is having a profound impact on healthcare delivery. Digital health uses data and technology to: - improve patient outcomes - improve access to healthcare - make more targeted and personalised health interventions - transform service delivery - deliver new treatments and translational medicine As this is the first DHTC call, we have deliberately gone with a broad scope.

Digital Health Technology Catalyst Feasibility Industrial Research and Experimental Development Total Project Costs £50,000 to £75,000 £500,000 to £1m Project Duration Up to one year 1 to 3 years Project Start Date By February 1st 2018 Project Type Single SME or collaboration Collaboration Project Lead UK based SME Application Process Single written Dates & Timelines Competition opens: 31st July ‘17 Registration by: 4th Oct ‘17 Application by: 11th Oct ’17

Precision medicine: impacting through innovative technology Precision Medicine Competition: Impacting through Innovative technology Innovate UK will invest up to £6 million in innovation projects to support the development of precision medicine (PM) technologies. Feasibility – for analysis and evaluation of a concept’s potential, identify the requirements and resources needed to develop the technology, and establish the prospects of success. Research  and development - for research and development applications, to develop and trial precision medicine technologies.  Projects must look to advance precision medicine by guiding decision-making using one of the following approaches: Developing tools to better integrate informatics and data. Establishing precision medicine clinical trials. Developing rapid diagnostics to inform better treatment decisions.

The UK’s innovation agency Precision Medicine Competition: Impacting through Innovative technology Feasibility projects : can last up to 12 months and have total project costs of up to £100,000. can be from a single SME or an SME working with other businesses or research organisations collaborative projects led by an SME Collaborative research and development projects : can last up to 24 months and have total project costs of between £1 million to £2 million. be collaborative and include at least 2 grant-claiming organisations be led by a UK based company or RTO of any size In this competition we are not funding projects that:  do not inform treatment decisions focus on drug discovery, biomarker discover, diagnostic tests for treatments that are still in development, unless justified as a parallel development, such as a companion diagnostic

The UK’s innovation agency Precision Medicine Competition: Impacting through Innovative technology You must explain clearly how your proposed technology will advance precision medicine. All proposals must offer innovative precision medicine technologies that improve the decision-making process for patient treatment selection Competition dates: Opens: 11th September 2017 Application Deadline: 25th October 2017 Applicants notified: 1st February 2018

We can’t stop thinking about the future Supporting UK businesses, researchers and clinicians across health and life sciences We can’t stop thinking about the future