CopiOs® Bone Void Filler

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Presentation transcript:

CopiOs® Bone Void Filler CopiOs Bone Void Filler is a synthetic bone graft substitute that creates an environment conducive to bone growth through its unique DICAL mineral component and its 3D collagen scaffold. Composition: CaHPO4 (DICAL) Optimal pH Level for Bone Healing Abundance of Localized Soluble Mineral Ions Osteoconductive Scaffold

Bone Formation (Osteogenesis) Triangle

CopiOs Composition – pH Level Optimal pH for Bone Healing Moderately acidic pH level promotes solubility of OI growth factors (5.5pH – 5.8pH) More soluble BMPs may remain available for bone healing processes in the early stages of bone growth

CopiOs Composition – Mineral Ions Abundance of Localized Soluble Mineral Ions Promotes Bone Formation DICAL provides significantly more Ca & PO4 ions at equilibrium than either ß-TCP or HA

CopiOs – Osteoconductive Properties Osteoconductive Scaffolds Provide Key Role in Bone Regeneration 3D collagen scaffold sponge resembles human cancellous bone and is 93% porous with interconnecting, multi-directional pores Sponge carrier wicks seven times its weight in autologous blood or bone marrow These osteoconductive attributes allow cellular attachment, nutrient and oxygen infiltration, and vascularization Microscopic view of collagen in CopiOs Sponge (200x) Microscopic view of collagen in CopiOs Paste (100x)