Anti-leprotics Chaulmoogra oil

OBJECTIVES On completion of this period you would be able to learn about The monograph of the anti-leprotic Drug CHAULMOOGRA OIL

Fig.44.1 Hydnocarpus Anthelmintica

CHAULMOOGRA OIL Syn : Hydnocarpus oil, Gynocardia oil (English) Nirodi vittula nune (Telugu) Biological Source : Fixed oil from seeds of Hydnocarpus anthelmintica Hydnocarpus heterophylla Family : Flacourtriaceae Geographical Sources : Myanmar, Thailand, Sri Lanka Bangladesh, East India (Assam and Tripura) Fig.44.2 Hydnocarpus tree

PREPARATION Seeds (Sub-ovoid, obtuse and angular, 2cm length, contain 40-45% fixed oil) Graded, machine decorticated, hydraulic pressed Oil Filter Yellow oil with characteristic odour and acrid taste

STANDARDS Acid Value : not less than 13 Saponification Value : 195-213 Iodine value : 93-104

CHEMICAL CONSTITUENTS Esters of unsaturated fatty acids of Chaulmoogric Acid (27%) Hydnocarpic Acid (48%) Glycerides of Palmitic Acid

USES The unsaturated fatty acids have strong bactericidal effect against Mycobacterium leprae Mycobacterium tuberculosis Useful in the treatment of Tuberculosis Leprosy, Psoriasis and Rheumatism FOR EXTERNAL USE ONLY Fig.44.4 Chaulmoogra oil

STORAGE AND SUBSTITUTES Stored in closed containers in cool place and protect from light Substitutes: Widely substituted by Hydnocarpus weightiana Hydnocarpus alpine

SUMMARY In this class we learnt about Chaulmoogra oil Contains unsaturated fatty acids Effective against Leprosy Caused by Mycobacterium leprae

QUIZ 1. The active constituents of Chaulmoogra oil are a) Alkaloids b) Unsaturated fatty acids c) Glycosides d) Tannins

QUIZ 2. Leprosy is caused by the organism a) Mycobacterium leprae b) Plasmodium vivax c) Entamoeba hystolytica d) None of the above

FREQUENTLY ASKED QUESTIONS 1. Write the Botanical Source and Chemical Constituents of Chaulmoogra 2. Give example for an Anti-leprotic drug. Write the Botanical Source and the Chemical constituents