Schizophrenia’s Heterogeneity
Schizophrenia’s Heterogeneity Positive Neuro/Motor Affective Negative Social Cognition Disorganization Neurocognition Anxiety OCS
Major Tranquilizers, Neuroleptics, Antipsychotics… 1930s 1940s 1950s 1960s 1970 1980 1990 2000 2002 FIRST GENERATION SECOND GENERATION THIRD… Clozapine Zotepine Amisulpride Reserpine Asenapine Lurasidone Olanzapine Paliperidone Quetiapine Risperidone Remoxipride* Sertindole* Ziprasidone Chlorpromazine Aripiprazole Haloperidol Fluphenazine Pimozide *withdrawn Adapted: Muller-Spahn 2002