Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells Abstract:

Slides:



Advertisements
Similar presentations
Cancer-inducing genes - CRGs (cooperation response genes) Paper Presentation Nadine Sündermann.
Advertisements

DNA Chip Scanning DNA Chips are scanned with a laser to excite the fluorescein dye that is attached to the target cDNA. Only those probe spots where target.
MiR-19b/20a/92a regulates the self- renewal and proliferation of gastric cancer stem cells Journal of Cell Science (IF=5.325) 报告人:黄美玲
Proliferation cluster (G12) Figure S1 A The proliferation cluster is a stable one. A dendrogram depicting results of cluster analysis of all varying genes.
Regrowing hair with laser and light sources: Is this practical? Michael R Hamblin PhD.
Supplemental figure 1: Correlation coefficients between signal intensities from biological replicates of wild.
Fig. 1. Schematic overview of diffusion maps embedding
Supplementary figure 5.
Characterization of Transition Metal-Sensing Riboswitches
Figure S2 A B Log2 Fold Change (+/- cAMP) Transcriptome (9hr)
Suppl. Figure 5. Non-sphere vs. sphere cell proliferation in vitro
Additional file 8: Estimation of biological variations
Skin Pharmacol Physiol 2017;30: DOI: /
Nick Barker, Hans Clevers  Gastroenterology 
Volume 21, Issue 11, Pages (December 2017)
Volume 154, Issue 3, Pages (February 2018)
HIV-1 Latency by Transition
Sensitivity of RNA‐seq.
Volume 3, Issue 4, Pages (April 2003)
P53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer  Crystal Tonnessen-Murray,
Is Hepatitis C Virus Carcinogenic?
Expression profiling of snoRNAs in normal hematopoiesis and AML
HIS-24 regulates expression of infection-inducible genes.
Modulation in Proteolytic Activity Is Identified as a Hallmark of Exogen by Transcriptional Profiling of Hair Follicles  Claire A. Higgins, Gillian E.
IL6 secretion is a hallmark of postsenescence.
Direct Conversion of Skin Cells into Blood: Alchemy or Science?
Dual LGR5 and KI67 knock‐in PDOs enable separation of quiescent and cycling LGR5+ CRC cells Dual LGR5 and KI67 knock‐in PDOs enable separation of quiescent.
Regulation of gene expression by FACT.
Coupling immunophenotypes to Drop‐seq data
Shiran Bar, Maya Schachter, Talia Eldar-Geva, Nissim Benvenisty 
Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data  Lara M.
Identification of Functional Patterns of Androgenetic Alopecia Using Transcriptome Profiling in Distinct Locations of Hair Follicles  Yong Miao, Qian.
Bmi-1 Regulates Extensive Erythroid Self-Renewal
Epidermal Differentiation: Transgenic/Knockout Mouse Models Reveal Genes Involved in Stem Cell Fate Decisions and Commitment to Differentiation  Maranke.
Bone Marrow–Derived Mesenchymal Stromal Cells from Patients with Sickle Cell Disease Display Intact Functionality  Elizabeth O. Stenger, Raghavan Chinnadurai,
Volume 146, Issue 4, Pages (August 2011)
Volume 3, Issue 4, Pages (April 2003)
Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors  Lara Rossi, Roberto M. Lemoli,
Volume 12, Issue 6, Pages (December 2003)
System approaches to analyze the effects of Zc3h10 knockdown
Volume 21, Issue 11, Pages (December 2017)
Differential Expression between Human Dermal Papilla Cells from Balding and Non- Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia 
Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells  Tomer Halevy, Christian Czech, Nissim.
Cluster analysis and pathway-based characterization of differentially expressed genes and proteins from integrated proteomics. Cluster analysis and pathway-based.
High Expression of CD200 and CD200R1 Distinguishes Stem and Progenitor Cell Populations within Mammary Repopulating Units  Gat Rauner, Tania Kudinov,
Characterization of differentially expressed proteins based on their COG classification. Characterization of differentially expressed proteins based on.
The BRD4 bromodomain is critical for expression of SASP genes.
Satoshi Itami, Shigeki Inui 
Shiran Bar, Maya Schachter, Talia Eldar-Geva, Nissim Benvenisty 
Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia  WenChieh.
Devendra S. Mistry, Yifang Chen, George L. Sen  Cell Stem Cell 
Xuepei Lei, Jianwei Jiao  Stem Cell Reports 
Volume 42, Issue 6, Pages (June 2011)
Significant differences in translational efficiencies of DNA damage repair pathway genes between patient clusters. Significant differences in translational.
Characterising dermis expansion and gene expression changes during mouse development (related to Fig 1)‏ Characterising dermis expansion and gene expression.
AZA treatment induces a distinct gene-expression pattern in stromal cells. AZA treatment induces a distinct gene-expression pattern in stromal cells. (A-C)
HOTAIR overexpression has marginal phenotypic and transcriptomic consequences on MDA‐MB‐231 HOTAIR overexpression has marginal phenotypic and transcriptomic.
Volume 15, Issue 12, Pages (June 2016)
Hair Follicles from Alopecia Areata Patients Exhibit Alterations in Immune Privilege- Associated Gene Expression in Advance of Hair Loss  Hoon Kang, Wen-Yu.
Intestinal differentiation is coupled with global rewiring of gene expression Intestinal differentiation is coupled with global rewiring of gene expression.
Volume 11, Issue 2, Pages (August 2018)
5mC-loss/5hmC-gain loci characterize neurogenic genes up-regulated during fate commitment. 5mC-loss/5hmC-gain loci characterize neurogenic genes up-regulated.
Supplemental Figure 1 Cell proliferation (% of mock)
Profiling of the TCRB-MYB cases by large-scale gene expression analysis. Profiling of the TCRB-MYB cases by large-scale gene expression analysis. (A) Heat.
Effects of NAT10 inhibition or depletion on gene expression.
Loss of BAP1 blocks T cell differentiation at the DN3 stage in vitro.
Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.
Cell Differentiation and Gene Expression
HOXA9 and STAT5 co-occupy similar genomic regions and increase JAK/STAT signaling. HOXA9 and STAT5 co-occupy similar genomic regions and increase JAK/STAT.
Volume 25, Issue 5, Pages e4 (May 2017)
Presentation transcript:

Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells Abstract: Androgenetic alopecia (AGA), also known as common baldness, is characterized by a marked decrease in hair follicle size, which could be related to the loss of hair follicle stem or progenitor cells. To test this hypothesis, we analyzed bald and non-bald scalp from AGA individuals for the presence of hair follicle stem and progenitor cells. Results: C2orf40 HYAL1 Figure 2: Sources of variation for the two differentially expressed genes. Figure 1: PCA mapping shows the complete separation between the two groups CD200+(red, bald) and CD200-(blue, not-bald) CD200+ CD200- HYAL1 C2orf40 Figure 3: Heat map showing the direct differential expression of the two genes that meet the threshold based p-value <0.05 and fold change of >2 or <-2 Figure 4: Volcano-plot of the differentially expressed genes p-value vs log-fold change based on 54,000 genes Conclusion: CD200+ cells exhibit decreased expression of HYAL1, which encodes hyaluronidase, an enzyme responsible for extracellular matrix degradation and cell proliferation. C2orf40 is upregulated. This ORF encodes a protein called auguring responsible for G1 to G0 cell cycle transition. Overexpression of this protein would keep cells in senescence. According to the paper, CD200+ cells are present in bald men which fits with the predicted effect of the differential expression of these genes.