Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass.

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Presentation transcript:

Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits Gabriel S. Aldea, MD, Louise O. Soltow, BS, Wayne L. Chandler, MD, Christopher M. Triggs, PhD*, Craig R. Vocelka, CCP, Gregory I. Crockett, CCP, Yong T. Shin, MD, William E. Curtis, MD, Edward D. Verrier, MD The Journal of Thoracic and Cardiovascular Surgery Volume 123, Issue 4, Pages 742-755 (April 2002) DOI: 10.1067/mtc.2002.120347 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Comparison of thrombin generation (PF-1.2) for different treatment strategies. Diamonds, Group I; squares, group II; triangles, group III. Asterisk indicates P <.001 for group I versus group III; plus sign indicates P =.042 for group II versus group III, by ANOVA and Scheffé test. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Comparison of PMNE for different treatment strategies. Diamonds, Group I; squares, group II; triangles, group III. Asterisk indicates P <.001 for group I versus group III; plus sign indicates P =.027 for group I versus group II, by ANOVA and Scheffé test. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Comparison of platelet activation (β-TG) for different treatment strategies. Diamonds, Group I; squares, group II; triangles, group III. Asterisk indicates P <.001 for group I versus group III; plus sign indicates P <.01 for group I versus group II, by ANOVA and Scheffé test. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 A, Comparison of NSE for different treatment strategies. Diamonds, Group I; squares, group II; triangles, group III. Asterisk indicates P <.001 for group I versus group III; plus sign indicates P <.001 for group II versus group III, by ANOVA and Scheffé test. B, Comparison of S100 for different treatment strategies Diamonds, Group I; squares, group II; triangles, group III. Asterisk indicates P =.005 for group I versus group III; plus sign indicates P =.035 for group II versus group III, by ANOVA and Scheffé test. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Correlation of post-CPB log10 PMNE and log10 β-TG. Diamonds, Group I; squares, group II; triangles, group III; line, total population. Pearson r = 0.75, P <.01. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Delayed memory, RAVLT VIII, by treatment group (box plots of difference scores). Score is based on asking patient to list as many of 15 words as are remembered after 20-minute break. P =.126 for group I versus group III, P >.20 for group II vs group III, by ANOVA and Scheffé test applied to difference scores. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 7 Symbol discrimination, written SDMT, by treatment group (box plots of difference scores). P =.054 for group I versus group III, P =.003 for group II versus group III, by ANOVA and Scheffé test applied to difference scores. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 742-755DOI: (10.1067/mtc.2002.120347) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions