Copyright © 1998 American Medical Association. All rights reserved. From: Lymphangitis and Refractory Lymphedema After Treatment With Topical Cantharidin Arch Dermatol. 1998;134(1):104-106. Figure Legend: A, Photograph of a 39-year-old woman demonstrating right lower leg edema 9 months after topical application of Cantharone for treatment of plantar verrucae; B, lymphangioscintigrams of both lower legs show rapid tracer transport bilaterally but with early interstitial dispersion (dermal "backflow") at the right ankle and calf at 17 minutes; C, persisting after gentle massage; and D, at 4 hours (boxed area). R indicates right; L, left. Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.

Copyright © 1998 American Medical Association. All rights reserved. From: Lymphangitis and Refractory Lymphedema After Treatment With Topical Cantharidin Arch Dermatol. 1998;134(1):104-106. Figure Legend: A, Bilateral leg lymphangioscintigrams of the same patient 26 months after treatment with Cantharone demonstrating progressive obliterative lymphangitis of the right lower leg and chronically impaired lymphatic drainage (lymphedema). Note the dispersion of tracer in the right lower leg at 18 minutes (A); B, persisting after gentle massage; and C, at 4 hours. In the normal left leg, tracer transport is prompt and well cleared at 4 hours. R indicates right; L, left. Date of download: 10/21/2017 Copyright © 1998 American Medical Association. All rights reserved.