Date of download: 10/21/2017 Copyright © ASME. All rights reserved. From: Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice J Biomech Eng. 2015;137(5):051011-051011-6. doi:10.1115/1.4029983 Figure Legend: The ROI analyzed for the histomorphometry were the OG (a) and the periosteal callus (b)

Date of download: 10/21/2017 Copyright © ASME. All rights reserved. From: Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice J Biomech Eng. 2015;137(5):051011-051011-6. doi:10.1115/1.4029983 Figure Legend: (A) A mouse connected to the motion application system. (B) The system was comprised of a linear actuator (a) that displaced the distal component (b) of the fixator while the proximal component (c) was fixed.

Date of download: 10/21/2017 Copyright © ASME. All rights reserved. From: Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice J Biomech Eng. 2015;137(5):051011-051011-6. doi:10.1115/1.4029983 Figure Legend: (A) External fixator surgically placed on the mouse tibia. The proximal (a) and distal (b) components of the fixator were secured to the bone via four rentention pins (c). The fixator was stabilized with the bar (d) secured to the proximal and distal components. (B) Radiograph at day 21 of a control tibia.

Date of download: 10/21/2017 Copyright © ASME. All rights reserved. From: Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice J Biomech Eng. 2015;137(5):051011-051011-6. doi:10.1115/1.4029983 Figure Legend: Histology of the midsagittal section through the OG after 7 days stained with Toluidine Blue for the control (a) and treatment (b) groups; VKM staining at day 12 (control (c) and treatment (d)), day 17 (control (e) and treatment (f)), and day 21 (control (g) and treatment (h)). * denotes cartilage. Scale bar = 1 mm.

Date of download: 10/21/2017 Copyright © ASME. All rights reserved. From: Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice J Biomech Eng. 2015;137(5):051011-051011-6. doi:10.1115/1.4029983 Figure Legend: Relative amounts of bone in the callus (a) and the OG (b) for the control and treatment groups at 7, 12, 17, and 21 days. The relative amount of bone within the OG at day 12 was significantly higher in the control group compared to the treatment group (*p ≤ 0.05).

Date of download: 10/21/2017 Copyright © ASME. All rights reserved. From: Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice J Biomech Eng. 2015;137(5):051011-051011-6. doi:10.1115/1.4029983 Figure Legend: Representative 3D reconstructions of control (a) and treatment (b) tibiae at day 21. Saggital cross sections illustrating the distribution of bone across the fracture gap for the control (c) and treatment (d) tibiae. TV (e) was not significantly different between groups while the BV/TV (f) was significantly higher in the control group compared to the treatment group (*p < 0.05).