PUD By Alaina Darby

Which of the following types of cells is stimulated by glucocorticoids to produce their beneficial effects in the stomach? Endocrine cells Mucous neck cells Parietal cells Chief cells b

All of the following stimulate parietal cells All of the following stimulate parietal cells. Which does not also stimulate ECL cells? Histamine Gastrin Acetylcholine a

Histamine receptor on the basolateral surface Which of the following is not a pharmacological site of intervention for PUD? H-K pump in the lumen Histamine receptor on the basolateral surface Prostaglandin receptor on the basolateral surface Histamine receptor on in the lumen d

Surface area on the basolateral surface increases When the parietal cells undergo morphological changes, which of the following occurs? Surface area on the basolateral surface increases Area that proton pumps occupy increases Area that histamine receptors occupy increases Area that prostaglandin receptors occupy increases b

Which of the following is properly matched? Gastric ulcers: increased gastric acid Duodenal ulcers: increased gastric acid GERD: inadequate bicarbonate secretion Gastric ulcers: inadequate bicarbonate secretion b

Duodenal ulcers can be caused by many factors. Which is the most common? NSAIDs Cancer H. Pylori Congenital defects c

When used alone, which is the most effective treatment for treating the underlying cause of peptic ulcer disease? Metroniazole PPI’s Tetracycline H2R antagonists c

H. pylori colonies have been found in the antrum of a patient’s stomach. Which of the following would not be a concern? Mucosal layer damage Increased cancer risk Endothelial damage Gastritis b

The H. pylori has spread and now evenly colonizes the entire stomach The H. pylori has spread and now evenly colonizes the entire stomach. Which of the following is not likely to occur? Hypertrophy Atrophy Hypochlorhydria Adenocarcinoma MALT lymphoma a

Which of the following is most effective at inhibiting basal, food-stimulated, and nocturnal gastric acid secretion? Nizatidine Esomeprazole Misoprostol Sucralfate b… even though nizatidine would do this a PPI does it better (irreversible, later in the cascade)

Which of the following antacids would be best for a patient who suffers from constipation? Magnesium salts Calcium salts Sodium bicarbonate Aluminum salts a

When counseling a patient taking antacids, which of the following would be most accurate? Aluminum: effects last longer when taken on an empty stomach, can cause constipation Aluminum: effects last longer when taken after a meal, can cause constipation Magnesium: effects last longer when taken on an empty stomach, can cause constipation Magnesium: effects last longer when taken after a meal, can cause constipation b

Which of the following protects the gastric lining but also has an advantage when taken with metronidazole? Misoprostol Sucralfate Bismuth compounds Omeprazole c

Which of the following reacts with hydrochloric acid to form a protective substance? Misoprostol Magnesium antacids Sucralfate Bismuth compounds c

Sucralfate, bismuth compound, ranitidine Which of the following drug therapy combinations is typical in treating H. pylori induced PUD? Sucralfate, bismuth compound, ranitidine PPI, clarithromycin, metronidazole PPI, ranitidine, metronidazole Antacid, ranitidine, clarithromycin b