A. High-power view of a normal pancreatic islet on H and E staining

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PANCREAS Objectives The student should be able to describe: 1.The endocrine part of the pancreas within the exocrine part. 2.The histological features.

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A. High-power view of a normal pancreatic islet on H and E staining A. High-power view of a normal pancreatic islet on H and E staining. The endocrine cells are arranged as irregular cords around abundant capillaries into which the hormone products are secreted. The islets are surrounded by clusters of acinar cells. No pancreatic ductal cells are seen in this image. B. H and E stain of a pancreatic endocrine tumor. Note the uniform, clustered nests of normal-appearing islet cells with scant mitosis. C. Pathology of a pancreatic endocrine tumor stained positive for chromogranin, a neuroendocrine tumor marker. The chromogranin is cytoplasmic and stains brown. D. Pancreatic endocrine tumor staining positive for gastrin, diagnostic of gastrinoma. Again, the staining is cytoplasmic. (A and B used, with permission, from Christine Iacobuzio-Donahue, MD, PhD, Johns Hopkins Medical Institutions, Baltimore, MD; C and D used, with permission, from Richard W. Goodgame, MD, University of Texas Medical Branch, Galveston, TX.) Source: Chapter 60. Endocrine Tumors of the Pancreas, Maingot's Abdominal Operations, 12e Citation: Zinner MJ, Ashley SW. Maingot's Abdominal Operations, 12e; 2013 Available at: http://accesssurgery.mhmedical.com/DownloadImage.aspx?image=/data/books/zinn12/zinn12_c060f002.png&sec=41816769&BookID=531&ChapterSecID=41808850&imagename= Accessed: October 21, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved