Mechanisms of Differentiation and Function of Regulatory T Cells

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Mechanisms of Differentiation and Function of Regulatory T Cells Oct. 11(Tue) 14:00 / Auditorium (1F), PBC Alexander Rudensky Memorial Sloan-Kettering Cancer Center The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and auto-inflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of Treg cells. The cellular and molecular mechanisms in the differentiation and function of these cells will be discussed. Inquiry: Dr. Dipayan Rudra (279-9865) or AIM Administrative Team (Tel.279-8628, E-mail: varsha@ibs.re.kr)