M1 Spring 2009 29 April 8 00 AM Neurotransmitter Transporters

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Presentation transcript:

M1 Spring 2009 29 April 8 00 AM Neurotransmitter Transporters Louis J De Felice, PhD Physiology and Biophysics

synaptic transmission (2009) action potential invades synapse neuron Voltage-gated ion channels pre vesicle neurotransmitter transporters neurotransmitters ligand-gated ion channels post vesicular transporter

5-HT NE Epi DA AMPH

glutamic acid

glutamate

GABA γ-Aminobutyric acid

Tyrosine > L-DOPA > DA > NE << OH Tyrosine > L-DOPA > DA > NE

Antidepressant Medications -SSRIs- Fluoxetine (Prozac) Citalopram (Celexa) Paroxetine (Paxil)

Monoamine Transporters and Disease SERT Obsessive Compulsive Disorder Anxiety Depression IBS serotonin DAT Attention Deficit/Hyperactivity Disorder Drug Dependence Schizophrenia dopamine NET Orthostatic Intolerance Depression Hypertension norepinephrine (noradrenalin)

Closer look at the synapse pre-synaptic vesicles