The amine hypothesis of major depression

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Presentation transcript:

The amine hypothesis of major depression The amine hypothesis of major depression. Depression appears to be associated with changes in serotonin or norepinephrine signaling in the brain (or both) with significant downstream effects. Most antidepressants cause changes in amine signaling. AC, adenylyl cyclase; 5-HT, serotonin; CREB, cAMP response element-binding (protein); DAG, diacyl glycerol; IP3, inositol trisphosphate; MAO, monoamine oxidase; NET, norepinephrine transporter; PKC, protein kinase C; PLC, phospholipase C; SERT, serotonin transporter. (Adapted from Belmaker R, Agam G: Major depressive disorder. N Engl J Med 2008;358:59.) Source: Antidepressant Agents, Basic & Clinical Pharmacology, 13e Citation: Katzung BG, Trevor AJ. Basic & Clinical Pharmacology, 13e; 2015 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1193/kat_ch30_f002.png&sec=69108258&BookID=1193&ChapterSecID=69108237&imagename= Accessed: October 21, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved