SWAG SSG Head and Neck Cancer Meeting Clinical Research Network West of England SWAG SSG Head and Neck Cancer Meeting Tuesday 12 September 2017 Research Report

Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltshire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network

NIHR CRN High Level Objectives 2017-18 Increase number of participants into NIHR CRN portfolio studies 650,000 in England 21,905 in West of England Increase the number of studies that deliver to time and target Target 80% Increase number of commercial studies delivered through network Reduce NHS study set up times Reduce time taken to recruit first participant

NIHR CRN Objectives for cancer 2017-18 Number of LCRNs achieving on-target recruitment into at least 8 of the 13 Cancer subspecialties, where "on-target" means either improving recruitment by 10% from 2016/17 or meeting the following recruitment targets per 100,000 population served:  a) Brain & CNS: 0.2; b) Breast: 8; c) Colorectal: 3; d) Paediatrics: 3; e) Gynae: 3; f) Head & Neck: 1; g) Haematology: 7; h) Lung: 4; i) Sarcoma: 0.1; j) Skin: 0.2; k) Supportive & Palliative Care and Psychosocial Oncology & Survivorship: 3; l) Upper GI: 3; m) Urology: 8.

2016/17 Recruitment to Head and Neck as % overall Cancer Incidence

Open studies – Head and Neck NCRI Tags Portfolio ID Project Title Site PI Trial Team Lead Early Stage Thyroid Cancer - Radiotherapy 10876 IoN - Is ablative radio-iodine necessary for low risk differentiated thyroid cancer patients Gloucestershire Hospitals Candish, Dr Charlie Chris Ford chris.ford@glos.nhs.uk University Hospitals Bristol Beasley, Dr Matthew Matt Baxter matt.baxter@uhbristol.nhs.uk Locally advanced squamous cell carcinoma - Chemotherapy 16203 NIMRAD - A randomised placebo-controlled trial of synchronous NIMorazole versus RADiotherapy alone in patients with locally advanced head and neck squamous cell carcinoma not suitable for synchronous chemotherapy or cetuximab Grant, Dr Warren Booz, Dr Hoda Observational/ 18621 CompARE Trial - Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer HPV positive - Adjuvant 18645 PATHOS - A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Royal United Hospitals Bath De Winton, Dr Emma Tom Tylee thomas.tylee@nhs.net Cancer of the Pharynx - Radiotherapy 19934 DARS - A phase III randomised multicentre study of dysphagia optimised intensity modulated radiotherapy (Do-IMRT) versus standard intensity modulated radiotherapy (S-IMRT) in head and neck cancer. Cook, Dr Audrey Recurrent/Metastatic - 2nd Line Treatment - Chemotherapy 20069 CANC 5086 - A Phase 1b/2, Open-Label, Multicentre Study Assessing Second Line Treatment in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Taunton and Somerset Jankowska, Dr Petra Not Known Medullary Thyroid Cancer - Observational 20272 QaLM - Assessment of Quality of Life Tools in Medullary Thyroid Cancer Observational Study - Only patients from original Head and Neck 5000 cohort 32797 Head & Neck 5000 Follow Up Study Thomas, Prof Steven

Studies in set up NCRI Tags Portfolio ID Project Title Site Thyroid Cancer - Radiotherapy 19937 SEL-I-METRY - Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy. University Hospitals Bristol Medullary Thyroid Cancer - Observational 20272 QaLM - Assessment of Quality of Life Tools in Medullary Thyroid Cancer Gloucestershire Hospitals Neutropic Melanoma - Post Operative Radiotherapy 30658 ANZMTG 01.09/TROG 08.09 - The RTN2 Study - A Randomised Trial of Post Operative Radiation Therapy Following Wide Excision of Neurotropic Melanoma of the Head and Neck Observational Study - Only patients from original Head and Neck 5000 cohort 32797 Head & Neck 5000 Follow Up Study

Useful links https://www.crn.nihr.ac.uk/ National and local network information including training programmes templates, tools, contacts, videos etc https://odp.nihr.ac.uk/ http:/ Open data platform. Look at performance across whole CRN including all specialty areas /csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and ‘in set up’ cancer studies https://www.ukctg.nihr.ac.uk/ See where a study is open across the country http://public-odp.nihr.ac.uk/  Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

Contacts Research Delivery Manager – david.rea@nihr.ac.uk Cancer portfolio facilitator – sarah.west@nihr.ac.uk Head and Neck research lead – steve.thomas@bristol.ac.uk