Genetics of common complex diseases: a view from Iceland

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Genetics of common complex diseases: a view from Iceland David O. Arnar, Runolfur Palsson European Journal of Internal Medicine Volume 41, Pages 3-9 (June 2017) DOI: 10.1016/j.ejim.2017.03.018 Copyright © 2017 European Federation of Internal Medicine Terms and Conditions

Fig. 1 Feasibility of identifying genetic risk variants by risk allele frequency and strengths of the genetic effects (odds ratio). From Manolio T, et al., Nature 2009;461:747–753, with permission. European Journal of Internal Medicine 2017 41, 3-9DOI: (10.1016/j.ejim.2017.03.018) Copyright © 2017 European Federation of Internal Medicine Terms and Conditions

Fig. 2 Manhattan plot summarizing results of genome-wide association meta-analysis of coronary artery disease. The −log10 (P value) is plotted against the physical position of each SNP on each chromosome. The threshold for genome-wide significance, P<5×10−8, is indicated by the horizontal line. From Nikpay M, et al., Nat Genet 2015;47:1121–1130, with permission. European Journal of Internal Medicine 2017 41, 3-9DOI: (10.1016/j.ejim.2017.03.018) Copyright © 2017 European Federation of Internal Medicine Terms and Conditions