Lymphatic system of the brain Lina Wetzel Kriti Bhatia

Facts June 1, 2015 published by Dr. Antoine Louveau and Jonathan Kipnis in Nature Changes in immunity of meninges during stress T-cells accumulated around dural sinuses in non-blood-containing vessels Immunohistochemistry  endothelial specific markers Also by fluorescent microscopy ( see course of the vessels)

Function meningeal lymphatics are capable of draining fluid from their surrounding environment Into deep cervical lymph nodes meningeal lymphatics contain T cells, B cells, and MHC class II-expressing myeloid cells

Neurological disease relevance New therapeutic targets for intervention of neurodegenerative diseases: Multiple sclerosis  Replases may be triggered by inflammatory response Alzheimer’s disease Amyotrophic lateral sclerosis