Volume 133, Issue 2, Pages 377-385 (February 2008) The Impact of Critical Illness on Perceived Health-Related Quality of Life During ICU Treatment, Hospital Stay, and After Hospital Discharge  Hofhuis Jose G.M. , MSc, Spronk Peter E. , MD, PhD, FCCP, van Stel Henk F. , PhD, Schrijvers Guus J.P. , PhD, Rommes Johannes H. , MD, PhD, Bakker Jan , MD, PhD  CHEST  Volume 133, Issue 2, Pages 377-385 (February 2008) DOI: 10.1378/chest.07-1217 Copyright © 2008 The American College of Chest Physicians Terms and Conditions

Figure 1 Flow diagram of the patients screened and included in the study. CHEST 2008 133, 377-385DOI: (10.1378/chest.07-1217) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

Figure 2 Diagram showing the changes from baseline values in the 252 patients surviving to 6 months following ICU discharge. Pre-ICU admission scores are set to zero-level. Negative changes denote a decline in HRQOL in the dimension or component score. Data are expressed as the mean ± SD. Differences between time points are given in Table 2. CHEST 2008 133, 377-385DOI: (10.1378/chest.07-1217) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

Figure 3 Radar chart of the HRQOL in long-term survivors at ICU admission and follow-up compared to the healthy control population. Solid line with square = normal population; interrupted line with circle = survivors pre-ICU admission; interrupted line with triangle = survivors at 6 months following ICU discharge. $ = pre-ICU admission vs healthy population (significant difference, Table 3); * = pre-ICU admission vs 6-month follow-up (significant difference, Table 2); # = 6-month follow-up vs healthy population (significant difference, Table 2). CHEST 2008 133, 377-385DOI: (10.1378/chest.07-1217) Copyright © 2008 The American College of Chest Physicians Terms and Conditions

Figure 4 Radar chart of the HRQOL before ICU admission in long-term survivors (n = 252) and nonsurvivors (n = 159) vs the healthy population. Solid line with square = healthy population; interrupted line with circle = survivors pre-ICU admission; interrupted line with diamond = nonsurvivors pre-ICU admission; $ = long-term survivors pre-ICU admission vs healthy population (significant difference, Table 3); * = nonsurvivors pre-ICU admission vs healthy population (significant difference, Table 3); # = pre-ICU admission long-term survivors vs nonsurvivors at 6-month follow-up vs healthy population (significant difference, Table 3). CHEST 2008 133, 377-385DOI: (10.1378/chest.07-1217) Copyright © 2008 The American College of Chest Physicians Terms and Conditions