Eric Niederhoffer SIU-SOM

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Eric Niederhoffer SIU-SOM 6/8/2018 Apoptosis Fas FasL TNF TNF-R1 Mit TRADD Cyt c FADD Caseff Cas8 Protein degradation DNase FasL: Fas ligand (cytokines, interferons, interleukins) Fas: Fas surface receptor (CD95 or APO1) FADD: Fas-associated death domain Cas8: cysteine-dependent aspartate-specific cysteine protease, caspase 8 Mit: mitochondrion Cyt c: cytochrome c Caseff: effector caspase TNF: tumor necrosis factor TNF-R1: tumor necrosis factor receptor TRADD: tumor necrosis factor-associated death domain DNase: deoxyribonuclease Cell death Eric Niederhoffer SIU-SOM

Review Questions Which proteins are involved in apoptosis? 6/8/2018 Review Questions Which proteins are involved in apoptosis? What are caspases? What is the function of caspases? What is the function of cytochrome c? What kinds of molecules are degraded during cell death?