Outline Immunity Artificial active immunization (vaccination) Types of vaccines Side effects Yes or no?
Vaccination Purposeful exposure to a controlled dose of harmless antigen to induce formation of antibodies => immune system produces large quantities of antibodies Vaccine – antigen (mix) used to induce artificial active immunity Primary purpose: immune memory Active immunity often remains throughout life
Why? One of the greatest public health successes of the last century Cost-effective weapon for prevention and control of infectious diseases Effective vaccine – reduced incidence of formerly epidemic childhood diseases (pertussis, poliomyelitis, tetanus, measles, mumps, rubella) Eradicated smallpox
Safety, effectiveness (branch of immune system), population, cost
Side effects and adverse events Like any medication, not 100% efficient Need for improvement of safety and efficacy Many vaccine do not reach the stage of year long clinical trials Injecting site reactions (pain, swelling, redness) Mild fever Shivering Fatigue Headache Muscle and joint pain
DTaP side effects
HepB vaccine side effects
HiB vaccine side effects
Polio vaccine side effects
Yes or no?
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