Fig. 7. Sirtuin 3 (SIRT3) deficiency removes the protective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition on oxidative stress and necrotic.

Slides:

Advertisements

Similar presentations

Pentose Phosphate Pathway Generation of NADPH and Pentoses COURSE TITLE: BIOCHEMISTRY 2 COURSE CODE: BCHT 202 PLACEMENT/YEAR/LEVEL: 2nd Year/Level 4, 2nd.

Advertisements

Oxidative Stress.

Volume 314, Issue 1, Pages (January 2012)

Fig. 3. Effect of JGH43IA on the glutamate-induced DNA fragmentation

Fig. 6. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition ameliorates ATP depletion induced by cisplatin in kidney proximal tubular cells. After 18 hours.

Increased Apoptosis, Altered Oxygen Signaling, and Antioxidant Defenses in First- Trimester Pregnancies with High-Resistance Uterine Artery Blood Flow

Fig. 6. Sirtuin 3 (SIRT3) deficiency removes the restorative effect of poly(ADP-ribose) polymerase 1 inhibition on forkhead box O3a (FOXO3a) transcription.

Selenium-deficient diet induces renal oxidative stress and injury via TGF-β1 in normal and diabetic rats Alluru S. Reddi, Jaya S. Bollineni Kidney International

Fig. 1. Growth inhibitory effects of IP6 on DU145 cells

Bovine lactoferricin B induces apoptosis of human gastric cancer cell line AGS by inhibition of autophagy at a late stage W.-R. Pan, P.-W. Chen, Y.-L.

Arterioscler Thromb Vasc Biol

K. Mertens, D. A. Lowes, N. R. Webster, J. Talib, L. Hall, M. J

Volume 68, Issue 3, Pages (September 2005)

Volume 12, Issue 4, Pages (October 2010)

Volume 85, Issue 3, Pages (March 2014)

Roles of antioxidant enzymes in corpus luteum rescue from reactive oxygen species- induced oxidative stress Kaïs H. Al-Gubory, Catherine Garrel, Patrice.

Involvement of mtDNA Damage Elicited by Oxidative Stress in the Arsenical Skin Cancers Chih-Hung Lee, Shi-Bei Wu, Chien-Hui Hong, Gwo-Shin Chen, Yau-Huei.

Oxidative stress in cataracts

Volume 44, Issue 5, Pages (May 2006)

Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage Venus W. Huang, B.Sc., Weie Zhao, M.B.B.S.,

Gianluca Tell, Carlo Vascotto, Claudio Tiribelli Journal of Hepatology

Fig. 7. Downstream effects of α-synuclein on mitochondria.

Acute Pancreatitis: Bench to the Bedside

Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis Reda Z. Mahfouz, M.D., Rakesh.

Volume 69, Issue 9, Pages (May 2006)

Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide.

Progranulin protects against renal ischemia/reperfusion injury in mice

Oxidative stress in Alzheimer's disease

Physiological Roles of Mitochondrial Reactive Oxygen Species

Testosterone promotes apoptotic damage in human renal tubular cells

Mitochondrial Dysfunction in Atrial Tissue of Patients Developing Postoperative Atrial Fibrillation Jelliffe Jeganathan, MBBS, Rabya Saraf, BA, Feroze.

Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury Zhe Wang, Sudhir.

Volume 86, Issue 1, Pages (July 2014)

Calcium phosphate–induced renal epithelial injury and stone formation: Involvement of reactive oxygen species Kinue Aihara, Karen J. Byer, Saeed R. Khan

Renal denervation prevents long-term sequelae of ischemic renal injury

Jinu Kim, Kelly E. Long, Kang Tang, Babu J. Padanilam

Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments Timo Wille, Herbert de Groot,

Progressive thermopreconditioning attenuates rat cardiac ischemia/reperfusion injury by mitochondria-mediated antioxidant and antiapoptotic mechanisms

Why NAD+ Declines during Aging: It’s Destroyed

Volume 143, Issue 3, Pages (September 2012)

Volume 25, Issue 1, Pages (March 2018)

Volume 66, Issue 5, Pages (November 2004)

Volume 81, Issue 7, Pages (April 2012)

Enyu Imai, Hideaki Nakajima, Jun-Ya Kaimori Kidney International

Membrane Redox State and Apoptosis: Death by Peroxide

The SirT3 Divining Rod Points to Oxidative Stress

Delphinidin, an Anthocyanidin in Pigmented Fruits and Vegetables, Protects Human HaCaT Keratinocytes and Mouse Skin Against UVB-Mediated Oxidative Stress.

Role of meprin A in renal tubular epithelial cell injury

Volume 65, Issue 3, Pages (March 2004)

Darcy L. Johannsen, Eric Ravussin Cell Metabolism

Acute Pancreatitis: Bench to the Bedside

Volume 89, Issue 2, Pages (February 2016)

Volume 7, Issue 1, Pages (July 2016)

Volume 67, Issue 1, Pages (January 2005)

Apoptosis and necroptosis result in mitochondria dysfunction and injury. Apoptosis and necroptosis result in mitochondria dysfunction and injury. L929.

Volume 70, Issue 4, Pages (August 2006)

Cytokine cooperation in renal tubular cell injury: The role of TWEAK

Volume 7, Issue 1, Pages (July 2016)

Wayel Jassem, Nigel D. Heaton Kidney International

Volume 64, Pages S52-S56 (October 2003)

MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical.

Ganesan Ramesh, W. Brian Reeves Kidney International

Haiyang Tang et al. BTS 2018;3:

Isyaku U. Yarube, Joseph O. Ayo, Rabiu A. Magaji, Isma’il A. Umar

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis G. McCreath, M.M.F. Scullion, D.A. Lowes,

Volume 77, Issue 10, Pages (May 2010)

Fig. 6. Increased oxidative stress in Nrf2-deficient cells

Volume 3, Issue 6, Pages (June 2006)

Volume 85, Issue 3, Pages (March 2014)

Therapeutic strategies targeting NAMPT against stroke.

Presentation transcript:

Fig. 7. Sirtuin 3 (SIRT3) deficiency removes the protective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition on oxidative stress and necrotic cell death in cisplatin-induced injury to kidney proximal tubule epithelial cells. (A) The level of lipid hydroperoxide was measured in SIRT3-KO and -WT cells treated with cisplatin plus PJ34 or vehicle. (B) The level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) was measured in the cells using an assay kit. (C) The mitochondrial membrane potential was measured using tetramethylrhodamine, ethyl ester assay. (D) The percentage of propidium iodide (PI)–positive cells was assessed in 10 field per well. (E) Scheme of PARP1-dependent SIRT3 pathway during cisplatin injury. FOXO3a, forkhead box O3a; MnSOD, manganese superoxide dismutase; GPX, glutathione peroxidase. n=4 experiments in each group. a)P<0.05 versus vehicle. b)P<0.05 versus WT. Fig. 7. Sirtuin 3 (SIRT3) deficiency removes the protective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition on oxidative stress and necrotic cell death in cisplatin-induced injury to kidney proximal tubule epithelial cells. (A) The level of lipid hydroperoxide was measured in SIRT3-KO and -WT cells treated with cisplatin plus PJ34 or vehicle. (B) The level of . . . Anat Cell Biol. 2016 Sep;49(3):165-176. http://dx.doi.org/10.5115/acb.2016.49.3.165