Results of Initial Operations in Non–Small Cell Lung Cancer Patients With Single-Level N2 Disease Yasuhiko Ohta, MD, Yosuke Shimizu, MD, Hiroshi Minato,

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Results of Initial Operations in Non–Small Cell Lung Cancer Patients With Single-Level N2 Disease Yasuhiko Ohta, MD, Yosuke Shimizu, MD, Hiroshi Minato, MD, Isao Matsumoto, MD, Makoto Oda, MD, Go Watanabe, MD The Annals of Thoracic Surgery Volume 81, Issue 2, Pages 427-433 (February 2006) DOI: 10.1016/j.athoracsur.2005.08.018 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Intramediastinal spread of metastasis related to the primary tumor sites. Open circles indicate skip metastasis; closed circles indicate non–skip metastasis. (LLL = left lower lobe; LUL = left upper lobe; RLL = right lower lobe; RML = right middle lobe; RUL = right upper lobe.) The Annals of Thoracic Surgery 2006 81, 427-433DOI: (10.1016/j.athoracsur.2005.08.018) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Kaplan-Meier survival plots for 94 non–small cell lung cancer patients with single-level N2 disease. The survival curve is combined with lines representing the 90% confidence interval. The Annals of Thoracic Surgery 2006 81, 427-433DOI: (10.1016/j.athoracsur.2005.08.018) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier survival plots for 94 non–small cell lung cancer patients with single-level N2 disease subdivided according to skip (n = 50; red lines) or non–skip (n = 44; green lines) status. The difference in survival between the two groups was significant (p = 0.015). The survival curves are combined with lines representing the 90% confidence interval. The Annals of Thoracic Surgery 2006 81, 427-433DOI: (10.1016/j.athoracsur.2005.08.018) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Immunohistochemical staining for D2-40 (A). In comparison with consecutive hematoxylin and eosin–stained section (B), D2-40 staining was detected predominantly in lymphatic vessels. No immunostaining was identified in the tumor cells or blood vessels. The Annals of Thoracic Surgery 2006 81, 427-433DOI: (10.1016/j.athoracsur.2005.08.018) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Immunohistochemical staining for vascular endothelial growth factor-C. Vascular endothelial growth factor-C antigens were mainly identified in the cytoplasm of tumor cells. The Annals of Thoracic Surgery 2006 81, 427-433DOI: (10.1016/j.athoracsur.2005.08.018) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions