Overview of the Lawrence D. Longo MD Center for Perinatal Biology

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Overview of the Lawrence D. Longo MD Center for Perinatal Biology 6/9/2018 Overview of the Lawrence D. Longo MD Center for Perinatal Biology

Lawrence D. Longo MD (1926-2016)

6/9/2018

6/9/2018

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology MISSION To advance innovative multidisciplinary and productive research to reduce the prevalence of chronic diseases by promoting healthy life style before conception, during pregnancy and in infancy and early childhood.

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology GOAL To prevent and treat developmental etiologies of adult diseases, and to provide an outstanding translational research environment that contributes to national and international leadership in the field of developmental programming of health and disease, and contributes to the Mission of Wholeness in the School of Medicine and University.

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology OPPORTUNITIES Environmental and Life Style Impact on Development Influence of Early Life Events on Health and Disease Understanding Complex Molecular Interactions

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology The poor diets and life style and negative environmental impact in girls and young women are causing disease in the next generations.

Developmental Programming of Health and Disease

Neurologic disorders Diabetes Atherosclerosis Hypertension Cancer Ischemic Heart Disease Malnutrition Hypoxia Smoking & Drugs

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology Major Focuses of Research Excellence Perinatal Stress and Developmental Programming of Heart and Cardiovascular Disease Perinatal Stress and Developmental Programming of Neurologic Disorders and Stroke Perinatal Stress and Developmental Programming of Metabolic Disease Perinatal Stress and Developmental Programming of Pulmonary and Respiratory Distress Prevention of Preterm Birth

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology Faculty Arlin Blood, PhD, perinatal stress and cerebral and pulmonary distress Charles A. Ducsay, PhD fetal hypoxia and metabolic disease Ravi Goyal, MD, PhD, perinatal stress and cerebral and neurologic disorders Xiangqun Hu, PhD, gestational hypoxia and maternal health Bo Li, PhD, perinatal stress and inflammation in neonatal brain injury Qingyi Ma, PhD, perinatal stress and neonatal brain injury Eugenia MataGreenwood, PhD, vitamin D deficiency and preeclampsia and asthma William J. Pearce, PhD, fetal hypoxia and brain development and stroke Gordon G. Power, MD, fetal cerebral and respiratory distress Christopher Wilson, PhD, inflammation and neural control of breathing in neontes Sean M. Wilson, PhD, fetal hypoxia and pulmonary disease Daliao Xiao, PhD, perinatal stress and hypertension Steven M. Yellon, PhD, prevention of preterm birth Lubo Zhang, PhD, perinatal stress and cardiovascular and neurologic disease

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology Extramural funding >$160 million Publications >1,500 PhD Graduate students >140 Postdoctoral fellows >180 Medical students in research >210

Center for Perinatal Biology The Lawrence D. Longo MD Center for Perinatal Biology Vision Improve Health and Wholeness through Innovative, Cooperative and Collective Efforts in Basic, Translational and Clinical Research.