Volume 6, Issue 1, Pages (July 2002)

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Volume 6, Issue 1, Pages 127-133 (July 2002) Increased Vascularity Detected by Digital Subtraction Angiography after VEGF Gene Transfer to Human Lower Limb Artery: A Randomized, Placebo-Controlled, Double- Blinded Phase II Study  Kimmo Mäkinen, Hannu Manninen, Marja Hedman, Pekka Matsi, Hanna Mussalo, Esko Alhava, Seppo Ylä-Herttuala  Molecular Therapy  Volume 6, Issue 1, Pages 127-133 (July 2002) DOI: 10.1006/mthe.2002.0638 Copyright © 2002 American Society for Gene Therapy Terms and Conditions

FIG. 1 Study protocol. Molecular Therapy 2002 6, 127-133DOI: (10.1006/mthe.2002.0638) Copyright © 2002 American Society for Gene Therapy Terms and Conditions

FIG. 2 Representative DSA at 3 months follow-up. (A) Control patient. PTA of anterior tibial artery occlusion. DSA demonstrates continued patency at the angioplasty site (arrow). There was no detectable increase in peripheral vascularity at follow-up. (B) VEGF-Ad patient. Infrapopliteal PTA. Follow-up DSA demonstrates continued patency of the gene-delivery site at proximal anterior tibial artery (arrow) and increased peripheral vascularity in comparison with post-PTA DSA. (C) VEGF-P/L patient. PTA of peroneal artery stenosis. Continued patency at the gene-delivery site (arrow) and increased peripheral vascularity in comparison with post-PTA DSA. Molecular Therapy 2002 6, 127-133DOI: (10.1006/mthe.2002.0638) Copyright © 2002 American Society for Gene Therapy Terms and Conditions