Metodología de la investigación cuantitativa FIBHUG

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Presentation transcript:

Metodología de la investigación cuantitativa FIBHUG Stefan Walter y Ángel Rodríguez

13 Absence of evidence is not evidence of absence

Outline Controlled Trials Linear Regression and Regression to the Mean Survival Analysis Odds Ratio Diagnostic Tests Transformation Interaction Missing Data

1. Controlled trials (Altman, Bland, Day, Schulz, Vickers, Kerry) 39. Treatment allocation in controlled trials: why randomise? 41. How to randomise. 50. Treatment allocation by minimisation. 44. Concealing treatment allocation in randomised trials. 43. Blinding in clinical trials and other studies. 61. Missing outcomes in randomised trials. 45. Analysing controlled trials with baseline and follow up measures.

Controlled trials 30. Trials randomised in clusters. 31. Analysis of a trial randomised in clusters. 32. Weighted comparison of means. 33. Sample size in cluster randomisation. 34. The intra-cluster correlation coefficient in cluster randomisation.

2. Linear Regression and Regression to the Mean 1. Correlation, regression, and repeated data 2. Regression to the mean 7. Some examples of regression to the mean

3. Survival Analysis 36. Time to event analysis 38. Survival probabilities (Kaplan-Meier method) 48. The log-Rank test

4. Odds Ratio 42. The odds ratio and logistic regression

5. Diagnostic Tests 3. Diagnostic tests 1: sensitivity and specificity 4. Diagnostic tests 2: predictive values 5. Diagnostic tests 3: receiver operating characteristics 49. Diagnostic tests 5: likelihood ratios

6. Transformations 17. Transforming Data 16. Logarithms 18. Transformations, means, and confidence intervals 19. The use of transformations when comparing two means

7. Interaction 24. Interaction 1: Heterogeneity of effects 25. Interaction 2: compare effect sizes not P values 26. Interaction 3: How to examine heterogeneity

8. Missing Data 53. Missing data

Controlled trials. Apoyo: Epiville http://epiville.ccnmtl.columbia.edu/ Randomized trials: http://epiville.ccnmtl.columbia.edu/randomized_trials/