Volume 123, Issue 10, Pages 2147-2157 (October 2016) Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography  Aarti Patel, BSc, MBChB, Ravi Purohit, MSc, BMedSci, Helena Lee, PhD, FRCOphth, Viral Sheth, BMedSci, Gail Maconachie, BMedSci, PhD, Eleni Papageorgiou, MSc, PhD, Rebecca J. McLean, MSc, PhD, Irene Gottlob, MD, FRCOphth, Frank A. Proudlock, MSc, PhD  Ophthalmology  Volume 123, Issue 10, Pages 2147-2157 (October 2016) DOI: 10.1016/j.ophtha.2016.06.057 Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 1 Optic nerve head tomograms of the left retina from an infant 9 months of age. A, Diametric parameters: (a) disc diameter, from nasal to temporal Bruch's membrane (red); (b) cup depth, vertical distance from cup base to midpoint of neuroretinal peaks (grey); (c) cup diameter, measured at midpoint of cup depth (blue). B, Peripapillary parameters measured at 1700 μm and 6.0° from central disc diameter: (d) retinal nerve fiber layer (RNFL), thickness measurement of hyperreflective tissue inferior to inner limiting membrane (ILM; green); (e) retinal thickness, thickness measurement from ILM to Bruch's membrane (purple). C, Natural scale image with basement membrane opening minimum rim width measurement: (f) yellow. Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 2 Scatterplots demonstrating the change of (A) optic disc diameter (in micrometers), (B) optic disc diameter (in degrees), (C) optic cup diameter (in micrometers), (D) optic cup diameter (in degrees), (E) cup-to-disc ratio, and (F) cup depth (in micrometers) with age (in months). Mean values (black line), 95% confidence intervals of the mean (grey line), and prediction interval (dashed line) are highlighted. Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 5 Scatterplots demonstrating the change of (A) temporal retinal nerve fiber layer (RNFL) measured at 1.7 mm from the disc center, (B) temporal RNFL measured at 6.0° from the disc center, (C) nasal RNFL measured at 1.7 mm from the disc center, and (D) nasal RNFL measured at 6.0° from the disc center with age (in months). Mean values (black line), 95% confidence intervals of the mean (grey line), and prediction interval (dashed line) are highlighted. Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 6 Scatterplots demonstrating the change of (A) temporal retinal thickness (RT) measured at 1.7 mm from the disc center, (B) temporal RT measured at 6.0° from the disc center, (C) nasal RT measured at 1.7 mm from the disc center, and (D) nasal RT measured at 6.0° from the disc center with age (in months). Mean values (black line), 95% confidence intervals of the mean (grey line), and prediction interval (dashed line) are highlighted. Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 3 Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 4 Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 7 Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 8 Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions

Figure 9 Ophthalmology 2016 123, 2147-2157DOI: (10.1016/j.ophtha.2016.06.057) Copyright © 2016 American Academy of Ophthalmology Terms and Conditions