p. = probable Von Willebrand factor A domain-containing protein 3B Exocyst complex component 2 Tripartite motif-containing protein 3 Heterogeneous nuclear ribonucleoprotein K p. small nuclear ribonucleoprotein Ly6/PLAUR domain-containing protein 1 Xaa-Pro dipeptidase SCO-spondin Protein argonaute-2 Citrate synthase WD repeat-containing protein 93 Tektin-2 Rhabdoid tumor deletion region protein 1 Phosphopantetheine adenylyltransferase Myosin-IIIb Filamin-C DnaJ homolog subfamilyl B member 13 UDP-glucose:glycoprotein glucosyltransferase 1 MOB kinase activator 3B Succinyl-CoA:3-keotacid coenzyme A transferase 1 Outer dense fiber protein 3 Rab GDP dissociation inhibitor β Uncharacterized WD repeat-containing protein Isocitrate dehydrogenase NADH dehydrogenase iron-sulfur protein 4 L-threonine dehydratase catabolic TdcB Meiosis-specific nuclear structural protein 1 Protein odr-4 homolog WD repeat-contianing protein 90 WD repeat-contianing protein 63 ATP synthase subunit δ p. cytochrome P450 Coiled-coil domain-containing protein 151 Dynein heavy chain 1 Tripartite motif-containing protein 2 Cystathionine gamma-lyase Serine/threonine protein kinase 25 EF-hand calcium-binding domain-containing protein 1 Dolichyl-diphosphooligosaccharide Kielin/chordin-like protein C9orf116 homolog Kyphoscoliosis peptidase Uncharacterized protein Receptor expression-enhancing protein 5 p. = probable N-acetylgalactosamine kinase GTP-binding protein Acetoacetyl-CoA synthetase Metabotropic glutamate receptor 2 Protein IoIS Ectoine hydroxylase α-aminoadipic semialdehyde synthase RuvB-like 2 Microsomal glutahione S-transferase 1 Tubby protein homolog Tyrosin-protein kinase p. dolichol-phosphate mannosyltransferase Guanine nucleotide-binding protein

Calcium-binding protein α-soluble NSF attachment protein Isocitrate dehydrogenase [NAD] subunit β Vacuolar protein sorting-associated protein 13C Cullin-1 C16orf62 homolog Circularly permutated Ras protein 1 Radial spoke head protein 4 homolog A ES1 protein homolog Apoptotic chromatin condensation inducer Caspase-7 Lachesin Twinfilin-2 Serine dehydratase-like Caspase-3 Syntaxin-5 Small nuclear ribonucleoprotein-associated protein Contactin Flotillin-2 p. cytochrome P450 tRNA methyltransferase 112 homolog Sterile α and TIR motif-containing protein 1

Von Willebrand factor A domain-containing protein 3B Exocyst complex component 2 Cell adhesion Cell-cell signaling Cell cycle and proliferation Cell organization and biogenesis Death Developmental processes DNA metabolism Protein metabolism RNA metabolism Signal transduction Stress response Transport Tripartite motif-containing protein 3 Heterogeneous nuclear ribonucleoprotein K Probable small nuclear ribonucleoprotein Xaa-Pro dipeptidase SCO-spondin Protein argonaute-2 Citrate synthase WD repeat-containing protein 93 Tektin-2 Rhabdoid tumor deletion region protein 1 Myosin-IIIb Filamin-C DnaJ homolog subfamilyl B member 13 UDP-glucose:glycoprotein glucosyltransferase 1 MOB kinase activator 3B Succinyl-CoA:3-ketoacid coenzyme A transferase 1 Outer dense fiber protein 3 Rab GDP dissociation inhibitor β Uncharacterized WD repeat-containing protein Isocitrate dehydrogenase NADH dehydrogenase iron-sulfur protein 4 L-threonine dehydratase catabolic TdcB Meiosis-specific nuclear structural protein 1 Protein odr-4 homolog WD repeat-containing protein 90 WD repeat-containing protein 63 ATP synthase subunit δ p. cytochrome P450 Coiled-coil domain-containing protein 151 Dynein heavy chain 1 Cystathionine gamma-lyase Serine/threonine protein kinase 25 EF-hand calcium-binding domain-containing protein 1 Dolichyl-diphosphooligosaccharide Kielin/chordin-like protein C9orf116 homolog Kyphoscoliosis peptidase Uncharacterized protein N-acetylgalactosamine kinase FIX: use highly significant proteins pCO2; differential expression skyline with GO Slim Blue = transport (GO slim) Orange = stress response Purple = developmental processes Green = RNA metabolism White = cell organization and biogenesis Red = death Black = protein metabolism Teal = cell adhesion Gray = cell-cell signaling pink = signal transduction Yellow = cell cycle and proliferation Brown = DNA metabolism If no dot: either other process or did not have low enough evalue or did not have match at all * Means > 10-fold difference GTP-binding protein Acetoacetyl-CoA synthetase Metabotropic glutamate receptor 2 Protein IoIS Ectoine hydroxylase α-aminoadipic semialdehyde synthase RuvB-like 2 Microsomal glutahione S-transferase 1 Tubby protein homolog Tyrosin-protein kinase Guanine nucleotide-binding protein *

Blue = transport (GO slim) Orange = stress response Cell adhesion Cell-cell signaling Cell cycle and proliferation Cell organization and biogenesis Death Developmental processes DNA metabolism Protein metabolism RNA metabolism Signal transduction Stress response Transport α-soluble NSF attachment protein Isocitrate dehydrogenase [NAD] subunit β Vacuolar protein sorting-associated protein 13C Cullin-1 C16orf62 homolog Circularly permutated Ras protein 1 Radial spoke head protein 4 homolog A ES1 protein homolog Apoptotic chromatin condensation inducer Caspase-7 Lachesin Twinfilin-2 Serine dehydratase-like Blue = transport (GO slim) Orange = stress response Purple = developmental processes Green = RNA metabolism White = cell organization and biogenesis Red = death Black = protein metabolism Teal = cell adhesion Gray = cell-cell signaling pink = signal transduction Yellow = cell cycle and proliferation Brown = DNA metabolism If no dot: either other process or did not have low enough evalue or did not have match at all * Means > 10-fold difference Syntaxin-5 Small nuclear ribonucleoprotein-associated protein Contactin Flotillin-2 p. cytochrome P450 tRNA methyltransferase 112 homolog Sterile α and TIR motif-containing protein 1