Progress and Plans

Morning Meeting - Chemistry Room 1.53g   08:30 – 09:00 Coffee on arrival – Chaston Chapman Lounge 09:00 – 09:10 Welcome - John Blacker 09:10 – 10:10 Progress Project Overview (John Blacker, Hayley Jackman) TSB Crystallisation (Xue Wang) Process Integration and Product Enhancement Through Crystal Growth Modifiers TSB Immobilisation (Patrick McGowan) 10:10 – 10:30 Scale up Webinar Feedback 10:30 – 11:00 Coffee – Chaston Chapman Lounge 11:00 – 12:00 CDT projects Chris Rayner, Frans Muller Break out to input into CDT projects Seminar - Engineering, Houldsworth Building, LTB (1.06) 12:00 – 13:00 Buffet Lunch - Houldsworth, Coffee Bar and/or Foyer Area 13:00 – 13:10 Welcome - John Blacker (University of Leeds) 13:10 – 13:40 Molecular modelling - Simone Tomasi (AstraZeneca) 13:40 – 14:10 Fit for purpose modelling - Frans Muller (University of Leeds) 14:10 – 14:40 Combined CFD and PBM modelling of a gas-liquid reactor - Chris Rielly (University of Loughborough) 14:40 – 15:15 Coffee - Houldsworth, Coffee Bar and/or Foyer Area 15:15 – 15:45 Population balance modelling of crystallisation and solids processes: the importance of domain knowledge- Sean Bermingham (PSE Enterprise) 15:45 – 16:15 Finite/Discrete element modelling - Dr Bao H Xu (University of Leeds) 16:15 Close

Project Grants EU FP7 outline proposal to Precision Manufacture of Nanoparticles (Limerick leading iPRD as partner) – alpha-rated unsuccessful but being re-iterated Innovative Medicines Initiative looking at green (bio)synthesis methods Chosen as preferred consortium - full application made. EU23m over 4 yrs. Consortium partners: 13 including iPRD, CoEBio3, York, Durham, Rostock, Antwerp, ACIB, Stuttgart, CatSci, Reaxa…. EPSRC Centre for Innovative Manufacture - EOI being submitted Simon Biggs leading, with partners Uni Birmingham Chem Eng. General area – Manufacture of functional (encapsulated) particles using continuous flow nano-membrane extrusion methodology Wide sector application - seeking industrial partners EPSRC Sustainable Chemical Feedstocks – Proposal being prepared (£2.5m) Collaboration with iPRD, Warwick (Lapkin, Bugg), CoEBio3 (Turner) General area – controlled biotransformation of lignin to simple polyphenolic broth and chemical modification to functionalised aromatic feedstocks

TSB Proposals Call - Sustainable Manufacturing for the Process Industry Project 1 – Predictive Work-Up. Currently discussing with AZ, KeyModule, Pfizer, Steven Abbott Associates, Chris Hunter (Sheffield), Peter Johnson (iPRD), Frans Muller (iPRD). Prediction of impurities traced through possible unit operations (mass balance); organic and aqueous solubility Project 2 – Chiral Amines. Currently discussing with AZ, Pfizer, YPT, Dr Reddys, AM Tech, Jianling Xiao (Liverpool), J Blacker, P McGowan, Steve Marsden (iPRD). Use of immobilised Cp* catalyst system in flow with different reactions to make chiral heterocyclic amines. Project 3 – Batch to Flow Catalyst Process. Currently discussing with CatExcel, J Blacker (iPRD). Advantages of carrying out a high energy transformation in flow.

MSc Projects Scope and development of some aromatic nucleophilic substitution reactions. JB and with Lyn Powell at AstraZeneca. Student Mr Gabriel Moran Malagon Direct asymmetric synthesis of chiral amines. JB and PM with Steve Fussel at Pfizer. Student Ms Nathalie Lam Exploiting the reactivity of carbon dioxide in fine chemical and pharmaceutical processing. Chris Rayner and John Blacker One-pot syntheses using multi-stage catalytic reactions. Steve Marsden and Simon Biggs Scale-up of the DyeCat Process. Richard Blackburn and Chris Rayner (with DyeCat Ltd) + 3more

Traffic Light View on Internal/External Partners and Funding UoL technology partners External funding/collaborative partners NMi Astbury Technology Strategy Board EPSRC EU Polymer IRC IPSE Particle CiC Healthcare BHRC Chemistry Innovation KTN BIS DCLG iPRD CPI (Wilton) IPI (Bradford)? BRITEST CoEBio3 (M’cr) IPOS (H’field) Industrial Club (ca. 15 companies) Strathclyde CPACT? UCL Biotech? External technology partners

iPRD Sustainability Prof. Muller + 2 Fellows Dr Hayley Jackman ERDF YF Grant Transformation Fund HEIF5 Project grants Contract work Industrial Club Prof. Muller + 2 Fellows Business development manager Dr Hayley Jackman Could terminate Sept 2012 Staff Costs Overheads Equipment + Maintenance Consumables