Pathophysiology of alcoholic liver disease

Slides:

Advertisements

Similar presentations

Surgical incision on a transplant patient The patient on antirejection medications (Prednisone and Cellcept) after liver transplant. Note the poor epithelial.

Advertisements

Some examples of glass capillary viscometers (A) and a schematic diagram showing measurement of time of flow between two points (1 and 2) in a viscometer.

Adhesive capsulitis of the shoulder

A, Diagnosis of clinical severity (mild, moderate, severe) of hemophilia is based on in vitro coagulant activity as shown. B, Distribution of severe and.

Spectrum of different types of human gene mutations logged in Human Gene Mutation Database as of September 13, 1998 ( Source: The.

Aphthous ulcers in Crohn disease

Large cell undifferentiated carcinoma of lung

(Copied with permission from: Latson, L. A. , & Prieto, L. R. (2007)

Sagittal T2-weighted MRI of lumbar spine showing multilevel disk bulges, ligamentum flavum hypertrophy, and retrolisthesis at L2-L3. Source: Neurosurgery,

IX; formation of sphingolipids, sphingosine is synthesised from L-serine and palmitoyl-CoA. Source: Serine deficiency disorders, The Online Metabolic and.

Desmoplastic small round cell tumor

Pathophysiology of esophageal reflux disease

Diagnostic approach: Dizziness.

Schematic representation of the DTDST protein

The cycle of injury and reinjury resulting from rotator cuff impingement. Source: Chapter 3. Sports Medicine, Current Diagnosis & Treatment in Orthopedics,

Invasive breast carcinoma

Normal gastroesophageal junction: Note the gastroesophageal junction in this picture which is defined by the junction of the normal pearly white esophageal.

Nine patterns of inflammatory skin disease. (See also Table 8–1.)

Forearm support for sustained work at the computer.

Diagnostic algorithm for normocytic anemia.

Upper panel shows a biopsy sample obtained from a normal volunteer and stained with periodic acid–Schiff (PAS) stain. The glycoprotein-rich epithelial.

Relation of H pylori infection to upper GI tract conditions

A: Esophageal varices: Upper endoscopy demonstrates four columns of esophageal varices. A consequence of portal hypertension, esophageal varices are one.

A. In monopolar electrosurgery, current from an electrosurgical generator passes from an active electrode (the “Bovie” tip) through the patient to a return.

Abnormal intracellular accumulations: (A) Fatty change in liver (alcoholic steatosis): Tissue processed for H&E staining (lipid extracted). (Inset): Frozen.

Radiograph of a giant cell tumor of the thumb

Staging of endometriosis

Major recommendation for statin therapy for ASCVD prevention

The typical course of acute and chronic hepatitis C

Sagittal T2-weighted MRI scan of a Chiari showing typical peg-like appearance of cerebellar tonsils and associated syringomyelia. Source: Neurosurgery,

Primary biliary cirrhosis

Imaging studies in a patient with a distractive flexion injury of the cervical spine. (A) This lateral radiographic view demonstrates anterior subluxation.

Schematic representation of the main divisions of the respiratory tract. (Reproduced, with permission, from Junqueira LC, Carneiro J: Basic Histology:

Intracellular location and overview of major metabolic pathways in a liver parenchymal cell. (AA →, metabolism of one or more essential amino acids; AA.

Survival rates after thyroidectomy for papillary, mixed papillary-follicular, follicular, medullary, and undifferentiated thyroid cancer. Source: Thyroid.

Internal hemorrhoids. (Used, with permission, from John Cello, MD.)

Technique of varicose vein stripping

Chronic hepatitis C infection

Ulcerative colitis. Note the continuous segment of mucosal erythema extending from the distal aspect of the specimen (right of image). This pattern of.

Subdivision of conducting airways and terminal respiratory units

Scaphoid fracture. A. Scaphoid fracture nonunion. B

Source: Dizziness, Symptom to Diagnosis: An Evidence-Based Guide, 3e

In diastolic dysfunction, the diastolic pressure-volume relationship is shifted upward and to the left (dashed line), which leads to an elevated left ventricular.

Hydronephrosis. A: Longitudinal scan from a patient with hydronephrosis due to chronic reflux. Numerous dilated fluid-filled spaces (calices) are seen.

(Data from Rosenfeld RL. N Engl J Med 2005; 353:2578–2588.)

Symptoms of alcohol withdrawal (Virtual Naval Hospital

Nonalcoholic steatohepatitis (NASH)

Spleen. Illustration showing the relationship of the splenic blood supply to the white pulp and the red pulp. (From Robbins Pathologic Basis of Disease,

Gallstones. Longitudinal ultrasonogram through the right upper quadrant. The gallbladder contains both sludge and stones (arrows). The gallstones are characteristically.

Small bowel Crohn disease.

Fatty liver. In some cases, the fatty change seen in alcoholics will involve the entire liver (i.e., diffuse fatty liver). Fatty liver can also occur with.

Ulcerative colitis. Double-contrast barium enema image shows numerous contrast-filled superficial ulcerations (arrows) with loss of normal colonic haustrations.

Sclerotherapy of telangiectasias using 0

Algorithm outlining an approach to the patient with dysphagia

Metastatic colon cancer

(Reproduced, with permission, from Emiliano Chavira, MD.)

Invasive breast carcinoma

Internal hemorrhoids. (Used, with permission, from John Cello, MD.)

FISH of glioblastoma. This interphase nucleus from a glioblastoma contains three chromosome 7 centromere signals (dark) and one centromere 10 signal (light).

Ischemic colitis. This example of ischemic colitis shows mucosal hemorrhage, necrosis of the superficial portions of the crypts, and lamina propria hyalinosis.

Gastrointestinal stromal tumor

Ulcerative colitis. White exudate is present overlying an abnormal colonic mucosa that has lost its typical vascular pattern. Source: Gastrointestinal.

Adapted with permission from Hiatt WR

Carotid angioplasty and stenting

Small bowel obstruction

Radiograph of a pathologic fracture secondary to Gaucher disease involving the distal femur in a 29-year-old man. Source: Chapter 5. Musculoskeletal Oncology,

Sensory distribution in the hand

(a) Sampling instruments, including a brush for cytology and biopsy forceps; (b) Snares and forceps for polypectomy/foreign body retrieval; (c) Needles,

Clinical and pathologic effects of hepatocellular failure, which commonly results from conditions associated with acute or chronic necrosis of liver cells.

(Redrawn, with permission, from Chandrasoma P, Taylor CR

Presentation transcript:

Pathophysiology of alcoholic liver disease Pathophysiology of alcoholic liver disease. This schematic diagram illustrates molecular mechanisms promoted by the intake and metabolism of alcohol in the liver, adipose tissue, and gastrointestinal tract (light boxes), contributing to characteristic pathologic changes in alcoholic liver disease (dark boxes). Source: Alcoholic Liver Disease, CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e Citation: Greenberger NJ, Blumberg RS, Burakoff R. CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e; 2016 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1621/gre_ch43_f001.png&sec=105186827&BookID=1621&ChapterSecID=105186806&imagename= Accessed: October 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved