Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor

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Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor Song Shen, PhD, Bei Ding, MD, Shengchang Zhang, MD, Xueyong Qi, PhD, Kun Wang, PhD, Jie Tian, PhD, Yongsheng Yan, PhD, Yanru Ge, PhD, Lin Wu, MD Nanomedicine: Nanotechnology, Biology and Medicine Volume 13, Issue 5, Pages 1607-1616 (July 2017) DOI: 10.1016/j.nano.2017.02.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Schematic illustration of the preparation of Fe3O4-PNIPAM yolk-shell nanocomposites and NIR-trigger drug release. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 TEM images of (A) Fe3O4-OA nanoparticles; (B) Fe3O4@SiO2 core-shell nanoparticles; (C) Fe3O4@SiO2-PNIPAM trilayer composites; (D) Fe3O4-PNIPAM yolk-shell nanoparticles after SiO2 layer was etched. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 3 (A) Absorbance spectra of free DOX (red, 90μg mL−1), Fe3O4-PNIPAM yolk-shell particles (blue, 50μg mL−1), and DOX-Fe3O4-PNIPAM particles (pink, 60μg mL−1); (B) Variation of the diameters of the Fe3O4-PNIPAM yolk-shell particles as a function of temperature. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 4 (A) MR images of Fe3O4-PNIPAM nanoparticles at different Fe concentration; (B) T2 relaxation rate (1/T2) of Fe3O4-PNIPAM nanoparticles as a function of iron concentration (mM); (C) MR images of MCF-7 cells incubated with the Fe3O4-PNIPAM nanoparticles at different Fe concentration; (D) Photothermal images of Fe3O4-PNIPAM nanoparticles at various concentration with different exposure time; (E) Photothermal temperature curves of Fe3O4-PNIPAM nanoparticles at various concentration with different exposure time; (F) Photoacoustic images before and after NIR irradiation: Fe3O4-PNIPAM particles and the cells treated with Fe3O4-PNIPAM nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 5 (A) Drug loading capacity of Fe3O4-PNIPAM yolk-shell nanoparticles and Fe3O4@SiO2-PNIPAM core-shell nanoparticles (*** P<0.001); (B) DOX release from DOX-Fe3O4-PNIPAM yolk-shell nanoparticles with or without NIR laser irradiation at water and PBS solution with different pH. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 6 Cell uptake of free DOX or DOX-Fe3O4-PNIPAM for 15min, 1h, 4h. Blue fluorescence of Hoechst 33,342 indicated the nuclei and red fluorescence indicated the DOX. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 7 In vivo imaging and biodistribution of Fe3O4-PNIPAM particles. Fluorescence images showing the in vivo imaging (A) and ex vivo (B) biodistribution of free ICG (200μL, 200μg·mL−1) and Fe3O4-PNIPAM-ICG (200μL, 10mg mL−1) after intravenous injection for 24h. (C) In vivo T2-weighted MR images of S180 tumor-bearing mice obtained 24h after intravenous injection of saline and Fe3O4-PNIPAM-ICG (200μL, 10mg mL−1); (D) MSOT images of S180 tumor-bearing mouse before and after injection of Fe3O4-PNIPAM (200μL, 10mg mL−1) showing overlaid HbO2, Hb and Fe3O4-PNIPAM signals. Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 8 Combined chemo-phototherapy in vivo. (A) Thermographic images of saline-injected (200μL) (Control) and Fe3O4-PNIPAM-injected (200μL, 10mg mL−1) (treatment) tumor-bearing mice under 808nm laser irradiation at a power density of 1.5W cm−2 with different time. (B) Tumor growth curves of S180 tumor following the different treatments. (C) Average weights of tumors at the end of 14 d treatments (*P<0.05, # P<0.05, ### P<0.001, by ANOVA with Tukey's post-test). (D) Photos of the tumors collected from different groups of mice at the end of treatments (day 14). Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions

Nanomedicine: Nanotechnology, Biology and Medicine 2017 13, 1607-1616DOI: (10.1016/j.nano.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions