Volume 164, Issue 2, Pages (October 2002)

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Volume 164, Issue 2, Pages 337-346 (October 2002) Evidence of insulin resistant lipid metabolism in adipose tissue in familial combined hyperlipidemia, but not type 2 diabetes mellitus Carla J.H van der Kallen, Christine Voors-Pette, Freek G Bouwman, Hans A Keizer, Jinyan Y Lu, René R.W.J van de Hulst, Ruut Bianchi, Marc-Jan Janssen, Eric T.P Keulen, Willy D Boeckx, Jerome I Rotter, Tjerk W.A de Bruin Atherosclerosis Volume 164, Issue 2, Pages 337-346 (October 2002) DOI: 10.1016/S0021-9150(02)00109-0

Fig. 1 GIR, indicating glucose disposal, during hyperinsulinemic euglycemic clamps in controls (n=16), FCHL (n=8) and DM2 (n=10) subjects. Controls reflect pooled data from eight young control subjects and eight age-matched controls (see text). *P<0.01 compared to controls. Atherosclerosis 2002 164, 337-346DOI: (10.1016/S0021-9150(02)00109-0)

Fig. 2 The time course of plasma glycerol (panel A) and FFA (panel B) concentrations during hyperinsulinemic euglycemic clamps in controls (□), FCHL (▴) and DM2 (●) subjects. In panel C and D, percent changes from baseline (100%) have been indicated. Data are mean±SEM. #P<0.05 FCHL vs controls; *P<0.05 DM2 vs controls. Atherosclerosis 2002 164, 337-346DOI: (10.1016/S0021-9150(02)00109-0)

Fig. 3 Insulin mediated suppression of glycerol and FFA in incubation buffer of control adipocytes in the presence (panel A) and absence (panel B) of isoprenaline (n=5–7). Data are mean±SEM. (panel A: 100%=50.4±25.8 nmol glycerol release/40,000 cells/2 h; panel B: 100%=25.3±11.6 nmol glycerol release/40,000 cells/2 h). Atherosclerosis 2002 164, 337-346DOI: (10.1016/S0021-9150(02)00109-0)

Fig. 4 Catecholamine stimulated lipolysis in incubation buffer of adipocytes (panel A: glycerol responses; panel B: FFA responses; basal: open bars; isoprenaline: closed bars, see also Table 2). Data are mean±SEM, and are expressed as nmol/40,000 cells/2 h. *P<0.05 (vs basal, two related sample test (Wilcoxon)); #P<0.05 vs DM2. Atherosclerosis 2002 164, 337-346DOI: (10.1016/S0021-9150(02)00109-0)

Fig. 5 Effect of insulin on glycerol (lipolysis) and FFA (lipolysis and re-esterification) in incubation buffer of adipocytes (panel A: glycerol responses; panel B: FFA responses; basal: open bars; insulin: closed bars, see also Table 2). Data are mean±SEM, and are expressed as nmol/40,000 cells/2 h. *P<0.05 (vs basal, two related sample test (Wilcoxon); #P<0.05 vs DM2. Atherosclerosis 2002 164, 337-346DOI: (10.1016/S0021-9150(02)00109-0)