Aromatase Inhibitors

About Aromatase Inhibitors Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women. They may also be used off- label to treat or prevent gynaecomastia in men. Aromatase is the enzyme that synthesizes estrogen. As breast and ovarian cancers require estrogen to grow, AIs are taken to either block the production of estrogen or block the action of estrogen on receptors. About Aromatase Inhibitors

Types Of Aromatase Inhibitors There are 2 types of aromatase inhibitors (AIs) approved to treat breast cancer: Irreversible steroidal inhibitors Such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme. Non-steroidal inhibitors Such as anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition for the aromatase enzyme. Types Of Aromatase Inhibitors

Exemestane Product

Details: Exemestane is a steroidal irreversible CYP19 (aromatase) inhibitor. Exemestane is structurally related to natural androstenedione and acts as a false CYP19 enzyme substrate. This effect is also known as "suicide inhibition". Exemestane has been found to inhibit human placental CYP19. Buy Exemestane of high quality only at Research Liquids. Exemestane

Description: Liquid Exemestane is an irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels. Targets: Aromatase Exemestane

Anastrozole Product

Details: Anastrozole belongs to a class of compounds known as aromatase inhibitors. An enzyme known as aromatase is responsible for producing estrogen by converting androgens into estrogen. Aromatase inhibitors like Anastrozole prevent aromatase from fulfilling that role by binding to it and rendering it inactive. Aromatase inhibitors fall into two categories: reversible (such as letrozole and Anastrozole ) and irreversible; irreversible aromatase inhibitors permanently bind to the circulating aromatase complex. Buy Anastrozole of high quality only at Research Liquids. Exemestane

Description: Liquid Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. Targets: Aromatase Exemestane

Letrozole Product

Details: Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells. Buy Letrozole of high quality only at Research Liquids. Letrozole

Description: Liquid Letrozole is a third generation nonsteroidal CYP19 aromatase inhibitor. Targets: CYP19 Letrozole

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