Distributed profile of brain activity identified in a data-driven Principal Component Analysis combining patients with major depression and healthy matched.

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Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
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Distributed profile of brain activity identified in a data-driven Principal Component Analysis combining patients with major depression and healthy matched control subjects in a positive emotional word condition, that correlates with group (diagnosis) membership. Note decreased cross-correlated ventral and medial striatal, medial prefrontal and precuneus activity, reflecting reward and default mode processing, in patients. With further developments and testing, such work may suggest patterns of circuit dysfunction distinguishing patients with depression or its subtypes, laying a foundation for future, clinically useful neuroimaging. Source: Special Populations and Settings, Depression in Medical Illness Citation: Barsky AJ, Silbersweig DA, Boland RJ. Depression in Medical Illness; 2016 Available at: http://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/1891/bar19084_c24_02.png&sec=138747247&BookID=1891&ChapterSecID=138744203&imagename= Accessed: October 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved