Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect.

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Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect Obes Facts 2015;8:110-124 - DOI:10.1159/000381163 Fig. 1. Changes in body weight before and after the operation in NC (n = 8), DM (n = 8), SRYGB (n = 8) and RYGB (n = 8) groups. *p < 0.05 compared with normal control group; #p < 0.05 compared with DM group and SRYGB group. Data are presented as mean ± SD. © 2015 S. Karger GmbH, Freiburg - CC BY-NC 3.0

Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect Obes Facts 2015;8:110-124 - DOI:10.1159/000381163 Fig. 2. Glucose tolerance. Blood glucose was measured at 0, 30, 60 and 120 min following administration of 1.5 g/kg bw glucose gavage in NC (n = 8), DM (n = 8), SRYGB (n = 8) and RYGB (n = 8) groups. *p < 0.05 compared with the normal control group; #p < 0.05 compared with the DM group and SRYGB group. Data are presented as mean ± SD. Blood glucose was measured A preoperatively, B 2 weeks and C 4 weeks postoperatively. D Area under the curve (AUC) of glucose. © 2015 S. Karger GmbH, Freiburg - CC BY-NC 3.0

Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect Obes Facts 2015;8:110-124 - DOI:10.1159/000381163 Fig. 3. Insulin level and HOMA. Serum insulin level was measured at 0, 30, 60 and 120 min following administration of 1.5 g/kg bw glucose gavage in NC (n = 8), DM (n = 8), SRYGB (n = 8) and RYGB (n = 8) groups. *p < 0.05 compared with the normal control group; #p < 0.05 compared with the DM group and SRYGB group. Data are presented as mean ± SD. Serum insulin was measured A preoperatively, B 2 weeks and C 4 weeks postoperatively. D HOMA-IR indexes. © 2015 S. Karger GmbH, Freiburg - CC BY-NC 3.0

Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect Obes Facts 2015;8:110-124 - DOI:10.1159/000381163 Fig. 4. Protein expressions of renal cortical G6Pase and PEPCK in NC (n = 8), DM (n = 8), SRYGB (n = 8) and RYGB (n = 8) groups. A representative immunoblot for G6Pase and PEPCK is shown. *p < 0.05 compared with the normal control group; quantitative densitometric analyses of the amount of G6Pase and PEPCK normalized to beta-actin. #p < 0.05 compared with the DM group and SRYGB group. Data are presented as mean ± SD. © 2015 S. Karger GmbH, Freiburg - CC BY-NC 3.0

Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect Obes Facts 2015;8:110-124 - DOI:10.1159/000381163 Fig. 5. Protein expressions of renal cortical IR-α and IR-β in NC (n = 8), DM (n = 8), SRYGB (n = 8) and RYGB (n = 8) groups. A representative immunoblot for IR-α and IR-β is shown. *p < 0.05 compared with the normal control group; quantitative densitometric analyses of the amount of IR-α and IR-β normalized to beta-actin. #p < 0.05 compared with the DM group and SRYGB group. Data are presented as mean ± SD. © 2015 S. Karger GmbH, Freiburg - CC BY-NC 3.0

Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect Obes Facts 2015;8:110-124 - DOI:10.1159/000381163 Fig. 6. Protein and phosphorylation expressions of renal cortical Gsk3b in NC (n = 8), DM (n = 8), SRYGB (n = 8) and RYGB (n = 8) groups. A representative immunoblot for GSK3 is shown. *p < 0.05 compared with the normal control group; quantitative densitometric analyses of the amount of Gsk3b normalized to beta-actin. #p < 0.05 compared with the DM group and SRYGB group. Data are presented as mean ± SD. © 2015 S. Karger GmbH, Freiburg - CC BY-NC 3.0