Volume 90, Issue 5, Pages 698-702 (November 1986) Evaluation of the Asthmogenicity of Propafenone, a New Antiarrhythmic Drug  Malcolm R. Hill, Pharm.D., Vincent P. Gotz, M.S., Eloise Harman, M.D., F.C.C.R, Ian McLeod, R.R.T, Leslie Hendeles, Pharm.D.  CHEST  Volume 90, Issue 5, Pages 698-702 (November 1986) DOI: 10.1378/chest.90.5.698 Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 1 Drug activity ratio in 12 volunteers with mild intermittent asthma during placebo and low-dose (450 mg/day) and high-dose (900 mg/day) therapy with propafenone. Low and high dosages represent ratio of PD20 after propafenone to placebo, whereas drug activity ratio during baseline represents ratio of PD20 at baseline to PD20 after placebo. Dashed line represents potentially important increase in airway reactivity to methacholine (ie, drug activity ratio <0.5). Mean drug activity ratio during high-dose regimen (0.63± 0.1 mg/ml) was significantly lower than mean ratio during low-dose treatment (0.93 ± 0.1 mg/ml) or baseline (1.2 ± 0.1 mg/ml) (p<0.01). CHEST 1986 90, 698-702DOI: (10.1378/chest.90.5.698) Copyright © 1986 The American College of Chest Physicians Terms and Conditions