Organic and biochemistry

Slides:



Advertisements
Similar presentations
Electrophilic Aromatic Substitution
Advertisements

Electrophilic Aromatic Substitution (Aromatic compounds) Ar-H = aromatic compound 1. Nitration Ar-H + HNO 3, H 2 SO 4  Ar-NO 2 + H 2 O 2.Sulfonation.
Organic Chemistry Reviews Chapter 15 Cindy Boulton March 29, 2009.
Mechanism of addition of HBr to an Alkene Step 1: Formation of a carbocation Step 2: Nucleophillic addition of bromide.
Lab 2.  It’s the aliphatic portion of the alkylbenzene.
Organic and biochemistry Assistance Lecturer Amjad Ahmed Jumaa  Reaction of alkene.  Addition reaction. 1.
Organic and biochemistry Assistance Lecturer Amjad Ahmed Jumaa o Nomenclature of the alkene  IUPAC nomenclature 1.
Nomenclature of Aromatic compounds  When a benzene ring is a substituent, the term phenyl is used (for C 6 H 5 - ) You may also see “Ph” or “  ” in place.
Structure and properties of benzene Nomenclature of Benzene.
Case Western Reserve University
1 Chapter 13 Unsaturated Hydrocarbons 13.7 Properties of Aromatic Compounds.
15.REACTIONS OF AROMATIC COMPOUNDS. Electrophilic Aromatic Substitution. ( approx. lecture time: 4 lectures) Topics covered: TNT, useful compound!
Chapter 9 Second Half. Electrophilic aromatic substitution electrophile (E + ) reacts with an aromatic ring and substitutes for one of the hydrogens The.
Aromatic Reactions Most common reactions for aromatics involve replacement of ring hydrogens by other atoms or groups (substitution reactions)
Chemistry of Aromatic Compounds
Chapter 4: Aromatic Compounds
CHEMISTRY OF BENZENE: ELECTROPHILIC AROMATIC SUBSTITUTION Dr. Sheppard CHEM 2412 Summer 2015 Klein (2 nd ed.) sections: 19.1, 19.2, 19.3, 19.4, 19.5, 19.6,
1 Benzene and Aromatic Compounds Buckminsterfullerene—Is it Aromatic? The two most common elemental forms of carbon are diamond and graphite. Their physical.
Benzene Reactions Dr AKM Shafiqul Islam School of Bioprocess Engineering University Malaysia Perlis.
CHEM 2211 Organic Chemistry I: Chapter 8 Summary of Reactions Know these!!!!! Slides 2-7 show the EAS reactions Slides 8-10 show the side chain reactions.
16. Chemistry of Benzene: Electrophilic Aromatic Substitution Part 2 Based on McMurry’s Organic Chemistry, 6 th edition, Chapter 16.
Chapter 8 Aromaticity Reactions of Benzene and Substituted Benzenes 1.
Chapter 16 The Chemistry of Benzene Derivatives. 2 MorphineValium.
Chapter 15 Reactions of Aromatic Compounds. Chapter 152  Electrophilic Aromatic Substitution  Arene (Ar-H) is the generic term for an aromatic hydrocarbon.
BenZene Ractions Dr Md Ashraful Alam Assistant Professor Department of Pharmaceutical Sciences.
Electrophilic Aromatic Substitution (EAS)Reactions Overall reaction.
Criteria for Aromaticity 1. The system must be cyclic 2. The system must be planar (flat) 3. Each ring atom must be part of a completely extended pi system.
Chapter 15 Reactions of Aromatic Compounds
Organic and biochemistry Assistance Lecturer Amjad Ahmed Jumaa  Reaction of the alkene.  Addition of hydrogen. 1.
Electrophilic Substitution Lab 1 Chemical reactions in which an electrophile displaces a group in a compound, typically but not always hydrogen.
Ch 19 Reactions of Benzene 1. Give the products of the following electrophilic aromatic substitution reactions. Also show how the electrophile is generated.
Aromatic Nitration - Mechanism
1 Figure 18.1 Five examples of electrophilic aromatic substitution.
Electrophilic Aromatic Substitution Dr. Marwa Eid 1.
Chapter 4: Aromatic Compounds Bitter almonds are the source of the aromatic compound benzaldehyde.
19.1 Introduction to Electrophilic Aromatic Substitution
Chemistry Department, College of Science, King Saud University
Chemistry Department, College of Science, King Saud University
When a benzene ring is a substituent, it is called a
Aryl Halides - Bonding, Physical Properties and Reactions
Reaction of Benzene and its Derivatives.
Chapter 11 Phenols.
Organic and biochemistry
Organic and biochemistry
11.10 Reactions of Arenes: A Preview
Chemistry of Aromatic Compounds
Energy Diagram =>.
Chemistry of Benzene: Electrophilic Aromatic Substitution
12/4/2018 CHEM 244 PRINCIPLES OF ORGANIC CHEMISTRY I FOR CHEMICAL ENGINEERING’ STUDENTS, COLLEGE OF ENGINEERING PRE-REQUISITES COURSE; CHEM 101 CREDIT.
Electrophilic Aromatic Substitution (Aromatic compounds)
Aromatic Compounds.
Pyridine Is Aromatic.
Friedel-Crafts Acylation of Benzene
Fundamentals of Organic Chemistry
As previously mentioned, benzene does not behave like alkenes in their characteristic reactions. Instead of addition reactions, benzene undergoes substitution.
Mechanism of Electrophilic Aromatic Substitution
Electrophilic Aromatic Substitution
Fundamentals of Organic Chemistry
4/30/2019 CHEM 240 PRINCIPLES OF ORGANIC CHEMISTRY I FOR CHEMISTRY’ STUDENTS, COLLEGE OF SCIENCE PRE-REQUISITES COURSE; CHEM 101 CREDIT HOURS; 2 (2+0)
Aromaticity of Benzenoid and Non-benzenoid compounds
Aromatic Compounds.
Fundamentals of Organic Chemistry
Fundamentals of Organic Chemistry
Fundamentals of Organic Chemistry
Reaction Mechanism in Aromatic hydrocarbons Batch: 2nd Semester Prof
Benzene and Aromatic Compounds
Fundamentals of Organic Chemistry
Fundamentals of Organic Chemistry
Presentation transcript:

Organic and biochemistry Reaction of the benzene Nitration Sulfonation Halogenation Assistance Lecturer Amjad Ahmed Jumaa

1-nitration Reactions of benzene Electrophilic aromatic substitution Just as the typical reactions of the alkenes are electrophilic addition reactions, so the typical reactions of the benzene ring are electrophilic substitution reactions. We see: Ar = aryl (any aromatic group with attachment directly to ring carbon). 1-nitration

Example: 2-halogenation. Example:

Nitration Sulfonation

Friedel-Grafts Alkylation Halogenation

Mechanism of the nitration