Thiazolidinediones and fluid retention

Slides:

Advertisements

Similar presentations

Pathophysiology of renal fluid retention

Advertisements

Volume 71, Issue 11, Pages (June 2007)

Volume 73, Issue 5, Pages (March 2008)

Figure 1 mTOR complex biology

Innate immunity as a driving force in renal disease

Volume 72, Issue 1, Pages (July 2007)

The pathway signalling starts with the binding of insulin or growth factors to insulin receptors. The pathway signalling starts with the binding of insulin.

Volume 79, Issue 1, Pages (January 2011)

Pathophysiology of renal fluid retention

Paolo Ferrari, M.D., Zygmunt Krozowski Kidney International

Volume 71, Issue 8, Pages (April 2007)

Volume 71, Issue 5, Pages (March 2007)

Kamel S. Kamel, Martin Schreiber, Mitchell L. Halperin

Defective neutrophil rolling and transmigration in acute uremia

Kidney International in 2007: Celebrating new features

Volume 70, Issue 11, Pages (December 2006)

Volume 73, Issue 4, Pages (February 2008)

Volume 71, Issue 11, Pages (June 2007)

G. Tripepi, K.J. Jager, F.W. Dekker, C. Wanner, C. Zoccali

Volume 73, Issue 1, Pages 5-7 (January 2008)

Volume 71, Issue 11, Pages (June 2007)

Volume 76, Issue 8, Pages (October 2009)

Cyclooxygenase-2 in the kidney: good, BAD, or both?

Spontaneous self-alkalinization in spontaneous tumor lysis syndrome

Volume 70, Issue 12, Pages (December 2006)

Disorders of the epithelial sodium channel: Insights into the regulation of extracellular volume and blood pressure Principal discussant: John B. Stokes

Volume 70, Issue 7, Pages (October 2006)

F. Verrey, P. Fakitsas, G. Adam, O. Staub Kidney International

Fructose intake as a risk factor for kidney stone disease

Volume 83, Issue 4, Pages (April 2013)

David M. Charytan, John P. Forman Kidney International

The third World Kidney Day: Looking back and thinking forward

Volume 19, Issue 5, Pages (September 2005)

Two channels for one job

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Calcium sensing in podocytes

mTOR and Akt Signaling in Cancer: SGK Cycles In

Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: therapeutic perspectives Pierre Ronco, Christos Chatziantoniou

What can be learned using microarrays?

S. Susan Hedayati, Essam F. Elsayed, Robert F. Reilly

Volume 57, Issue 4, Pages (April 2000)

Volume 71, Issue 4, Pages (February 2007)

Volume 60, Issue 2, Pages (August 2001)

Volume 71, Issue 11, Pages (June 2007)

Leptin and inflammation-associated cachexia in chronic kidney disease

Organ transplantation goes to the movies

Volume 69, Issue 1, Pages (January 2006)

Véronique Vallet, Jean-Daniel Horisberger, Bernard C. Rossier

Molecular origin of the kidney clock

Volume 82, Issue 6, Pages (September 2012)

Volume 72, Issue 11, Pages (December 2007)

Is it the low-protein diet or simply the salt restriction?

Is complement a target for therapy in renal disease?

Volume 70, Issue 3, Pages (August 2006)

Volume 70, Issue 5, Pages (September 2006)

WNK kinases regulate sodium chloride and potassium transport by the aldosterone- sensitive distal nephron A.R. Subramanya, C.-L. Yang, J.A. McCormick,

Volume 57, Issue 4, Pages (April 2000)

Volume 75, Issue 7, Pages (April 2009)

Volume 72, Issue 11, Pages (December 2007)

T cells and T-cell receptors in acute renal failure

The International Pediatric Peritonitis Registry: Starting to walk

Thiazolidinediones and fluid retention

Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Volume 74, Issue 11, Pages (December 2008)

Regulation of ENaCs by proteases: An increasingly complex story

Volume 72, Issue 12, (December 2007)

Model of regulatory pathways for the mineralocorticoid receptor (MR) in intercalated cells: hyperkalemia and volume depletion. Model of regulatory pathways.

Sickle cell trait and gross hematuria

The Ribosome and TORC2: Collaborators for Cell Growth

Presentation transcript:

Thiazolidinediones and fluid retention K. Kiryluk, R. Isom Kidney International Volume 72, Issue 6, Pages 762-768 (September 2007) DOI: 10.1038/sj.ki.5002442 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Portable AP view of the chest demonstrates cardiomegaly, perihilar edema, and blunting of the left costophrenic angle, consistent with congestive heart failure. Kidney International 2007 72, 762-768DOI: (10.1038/sj.ki.5002442) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Aldosterone and Sgk1–Nedd4-2–ENaC Pathway (left) and effects of PPAR-γ activation (right). Aldosterone interacts with its mineralocorticoid receptor (MR) and directly upregulates the mRNA levels of ROMK, ENaC-α, and Sgk-1. Sgk-1 inactivates Nedd4-2, stimulates basolateral Na+K+ATP-ase, and activates ROMK (data not shown in this panel). The right panel illustrates a possible convergence point of the insulin and TZD-mediated pathways at Sgk-1 level. Thiazolidinediones (TZDs) activate PPAR-γ, which in turn increases the expression of ENaC-γ and inactive form of Sgk-1 (although not confirmed by Guan et al.). Insulin acts via phosphatidylinositol 3-kinase (PI3K) and phosphoinositide-dependant kinase (PDK) pathway which converts inactive Sgk-1 to its active form by phosphorylation. *the PY motif-mediated interaction between ENaC subunits and ubiquitin ligase Nedd4-2. Kidney International 2007 72, 762-768DOI: (10.1038/sj.ki.5002442) Copyright © 2007 International Society of Nephrology Terms and Conditions