– Color Index: Important. Extra Information. Doctors slides.

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– Color Index: Important. Extra Information. Doctors slides. Carbohydrates Revised by شوق الأحمري & طراد الوكيل – Color Index: Important. Extra Information. Doctors slides. 436 Biochemistry team

Objectives: The structure of carbohydrates of physiological significance. The main role of carbohydrates in providing and storing of energy. The structure and function of glycosaminoglycans.

Carbohydrates (CH2O)n Purpose “hydrates of carbon” Are the most abundant organic molecules in nature Purpose Provides and stores energy Structural component in cell membranes Empiric formula: (CH2O)n “hydrates of carbon” Some carbohydrate metabolism disorders: Diabetes mellitus : a chronic disease associated with abnormally high levels of the sugar glucose in the blood. Galactosemia : condition in which the body cannot process or 'metabolise' the sugar galactose. Which means High galactose level in the blood Glycogen storage disease :  is the result of defects in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types Lactose intolerance : is the inability of adults and children to digest lactose

-One chain but it has a branch on it Heteropolysaccharides Classification Monosaccharides Simple sugar Disaccharides 2 sugar units Oligosaccharides 3-10 sugar units Polysaccharides >10 sugar units Homopolysaccharides Same sugar unit multiple copies Branched -One chain but it has a branch on it glycogen and starch (a-glycosidic polymer) Unbranched -Single chain Cellulose (B-glycosidic polymer) Heteropolysaccharides Different sugar units multiple copies

Monosaccharides Are further classified based on: Carbonyl group in the 2nd position (within the chain) Carbonyl group at the end 1- No. of Carbons 2- Functional Sugar group ( Aldose & Ketose ) Aldose Ketose Triose Glyceraldehyde Dihydroxyacetone Pentose Ribose Ribulose Hexose Glucose Fructose The smallest Aldehyde is Glyceraldehyde. Hexose is the most common functional group Glucose -> Aldehyde group Fructose -> Ketone group

*You don’t have to memorize structures

Mutarotation Sugar Isomers: *You don’t have to memorize structures + Temperature In solution, the cyclic α and β anomers of a sugar are in equilibrium with each other, and can be interconverted spontaneously. Alpha and beta are not fixed in the solution + converting from beta to alpha not required any energy or enzymes when Sugar Isomers: Aldo-Keto Same : formula Different : functional Group Epimers Different : configuration around a *single* carbon atom D-and L-forms Same : molecular formula Different : position of OH group on the *asymmetric carbon* farthest from carbonyl group α-and β-anomers Different : position of OH around anomeric carbon

Disaccharides Joining of 2 monosaccharides by O-glycosidic bond . *You don’t have to memorize structures Disaccharides Joining of 2 monosaccharides by O-glycosidic bond . Examples : 1-Maltose(α-1, 4)= glucose + glucose 2- Sucrose (α-1,2)= glucose + fructose 3- Lactose (β-1,4)= glucose + galactose C1 of the first glucose OH toward down C4 of the second glucose NOTE: α= OH down Β= OH up

Polysaccharides Examples : Branched Unbranched Examples : Examples : Homopolysaccharides Heteropolysaccharides Homo: same type of suger Hetero: different type of suger Examples : Glycosaminoglycans ( GAGs) Branched Unbranched Examples : Glycogen and starch (α-glycosidic polymer) Examples : Cellulose (β-glycosidicpolymer)

*Sucrose is non-reducing, Why? Monosaccharides Maltose Lactose Examples Reducing Sugars If the hydroxyl group on the anomeric carbon of a cyclized sugar is not linked to another compound by a glycosidic bond, the ring can open. The sugar can act as a reducing agent, and is termed a reducing sugar. Such sugars can react with chromogenic agents (for example, Benedict’s reagent or Fehling’s solution) causing the reagent to be reduced and colored, with the aldehyde group of the acyclic sugar becoming oxidized. If the O on the anomeric C of a sugar is not attached to any other structure (Free), that sugar can act as a reducing agent Reducing sugars reduce chromogenic agents like Benedict’s reagent or Fehling’s solution to give a colored precipitate Urine is tested for the presence of reducing sugars using these colorimetric tests *Sucrose is non-reducing, Why? Sucrose is the combination of cyclic structures of Glucose and Fructose and therefore does not have a free aldehyde or ketone group. http://www.youtube.com/watch?v=Kj15mH5zB6Y&t=7m55s الفيديو جدا رائع يفسر بطريقة جدا مفهومة وبسيطة

Complex Carbohydrates Carbohydrates attached to non- carbohydrate structures by glycosidic bonds (O- or N-type). Carbohydrates can be attached by glycosidic bonds to non-carbohydrate structures, including purine and pyrimidine bases Glycoproteins; proteins that have some sugar attached to it. Proteoglycans:carbohydrate having some protein attached to it. Glycolipids: lipids that have some sugar attached to it

Glycosidic Bonds N-Glycosidic O-Glycosidic If the group on the non-carbohydrate molecule to which the sugar is attached is an –NH2 group, the structure is an N-glycoside and the bond is called an N-glycosidic link. O-Glycosidic If the group is an –OH, the structure is an O-glycoside, and the bond is an O-glycosidic link Polar and charged

*Since it’s negatively charged it can form bonds with water

Resilience of GAGs

Carbohydrates (CH2O) Monosaccharides Can be classified according to: Disaccharide Oligosaccharide Polysaccharide (more than 10) (3-10) monosaccharide Functional gr. NO.Of C atoms "2 Mono units" Bond: O-glycosidic *Sucrose= glucose+fructose * Maltose= glucose+glucose *Lactose= glucose+galactose Homopolysaccharide Aldoses Ketoses Glyceraldehyde Ribose glucose Trios "3C" Pentos "5C" Hexos "6C" Dihydroxyacetone Ribulose fructose Branched Unbranched *glycogen *cellulose *starch Heteropolysaccharide e.g: Glycosaminoglycan (GAG) *it has a negative charge *Linear *forms Proteoglycan, it has 95% carbohydrates *forms a Gel-like matrix *forms viscous and lubricating the mucos (mucopolysaccharide) *consists of repeated disaccharide units Amino sugar (sulfated) Acidic sugar D-glucosamine D-glucuronic acid Or D-galactosamine L-iduronic acid

videos Quiz Naming and classification Cyclic structure of carbohydrates Quiz

twitter.com/436biochemteam Girls team members: 1- زينة الكاف. 2- جومانا القحطاني. 3- ريم السرجاني. 4- شذا الغيهب. 5- سارة الشمراني. 6- لجين الزيد. 7- روان الوادعي. 8- هيفاء الوعيل. 9- روان القحطاني. 10- لمى الفوزان. 11- بثينة الماجد. -Team leaders: نوره السهلي. عبدالله المانع. -Contact us: Biochemistryteam436@gmail.com twitter.com/436biochemteam