Analysis of nonspecific oral mucosal and dermal lesions suggestive of syphilis: a report of 6 cases  Natalie Kelner, DDS, MSc, Gustavo Davi Rabelo, DDS, MSc, Danyel Elias da Cruz Perez, DDS, PhD, José Narciso Rosa Assunção, DDS, MSc, Andrea Lusvarghi Witzel, DDS, PhD, Dante Antônio Migliari, DDS, PhD, Fabio Abreu Alves, DDS, PhD  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  Volume 117, Issue 1, Pages 1-7 (January 2014) DOI: 10.1016/j.oooo.2012.04.028 Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 1 A, Patient 1: ulcer covered by a fibrin membrane with erythematous rolled border on upper lip. B, Patient 2: submucous nodule with superficial erosion located on the tongue. C, D, Patient 3: ulcers and erosion on hard palate; fissure in retromolar region. E-G, Patient 4: patches affecting palate, lip, and buccal mucosa. H, Patient 5: erythematous area and fissures on tongue. I, Patient 6: multiple papules on palate. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2014 117, 1-7DOI: (10.1016/j.oooo.2012.04.028) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 2 Skin lesions. A, Patient 3: erythematopapular lesions on the neck. B, Patient 4: red-brown scaling macules on the palms. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2014 117, 1-7DOI: (10.1016/j.oooo.2012.04.028) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 3 Histopathologic findings. A, Inflammatory infiltrate composed of plasma cells and macrophages in the connective tissue, showing a pseudogranulomatous or vortex-like organization of this infiltrate (hematoxylin-eosin stain, ×200). B, Evidence of the abundance of plasma cells (hematoxylin-eosin stain, ×400). C, Immunohistochemical method: spirochetes are visible in the lamina propria (×200). D, Immunohistochemistry: spirochete colored brown (arrow) (×400). Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2014 117, 1-7DOI: (10.1016/j.oooo.2012.04.028) Copyright © 2014 Elsevier Inc. Terms and Conditions