Methylation and Expression Analyses of the 7q Autism Susceptibility Locus Genes <b><i>MEST</i></b>, <b><i>COPG2,</i></b> and <b><i>TSGA14</i></b> in Human.

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Figure S1: Scatter plots of DNA methylation determined by Illumina (X-axis) and pyrosequencing (Y-axis) at overlapping CpG sites. Grey diamonds are cases.

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Methylation and Expression Analyses of the 7q Autism Susceptibility Locus Genes <b><i>MEST</i></b>, <b><i>COPG2,</i></b> and <b><i>TSGA14</i></b> in Human and Anthropoid Primate Cortices Cytogenet Genome Res 2012;136:278–287 - DOI:10.1159/000337298 Fig. 1. Distribution of MEST, COPG2, and TSGA14 promoter methylation values in 13 human, 3 chimpanzee, 3 baboon, 1 rhesus macaque, and 5 marmoset cortices. Medians are represented by horizontal lines. The bottom of the boxes indicates the 25th percentiles, the top the 75th percentiles. The T bars extend from the boxes to at most 1.5 times the height of the box. Outliers are shown as open circles. © 2012 S. Karger AG, Basel - CC BY-NC 3.0

Methylation and Expression Analyses of the 7q Autism Susceptibility Locus Genes <b><i>MEST</i></b>, <b><i>COPG2,</i></b> and <b><i>TSGA14</i></b> in Human and Anthropoid Primate Cortices Cytogenet Genome Res 2012;136:278–287 - DOI:10.1159/000337298 Fig. 2. Alignment of the human MEST, COPG2, and TSGA14 oligonucleotide probes and the orthologous chimpanzee (PTR), baboon (PHA), and marmoset (CJA) sequences. For the anthropoid primate sequences, only the bases that differ from the human reference sequence are shown; base positions identical to the reference are indicated by dots. © 2012 S. Karger AG, Basel - CC BY-NC 3.0

Methylation and Expression Analyses of the 7q Autism Susceptibility Locus Genes <b><i>MEST</i></b>, <b><i>COPG2,</i></b> and <b><i>TSGA14</i></b> in Human and Anthropoid Primate Cortices Cytogenet Genome Res 2012;136:278–287 - DOI:10.1159/000337298 Fig. 3. Box plots showing ratio and range of COPG2 and TSGA14 expression in anthropoid primate versus human cortices. Bottom and top of the boxes indicate the 25th and the 75th percentiles, respectively. Horizontal lines represent the median determined by REST analysis of real-time RT PCR data. T bars represent the minimum and maximum of 10,000 iterations performed. An expression ratio of 1 is consistent with equal expression levels in the 2 analyzed species; values <1 and >1 indicate down- and upregulation, respectively, in the analyzed anthropoid primate compared to the human cortex. © 2012 S. Karger AG, Basel - CC BY-NC 3.0