Time related changes of T1, T2, and T2* of human blood in vitro

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Time related changes of T1, T2, and T2* of human blood in vitro Andreas Petrovic, Astrid Krauskopf, Eva Hassler, Rudolf Stollberger, Eva Scheurer Forensic Science International Volume 262, Pages 11-17 (May 2016) DOI: 10.1016/j.forsciint.2016.02.032 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Staging scheme for intracranial hematomas showing the age, dominant Hb species, and relaxation times according to Bradley et al. [3]. The corresponding stages are hyperacute (<24h), acute (1–3d), early subacute (>3d), and late subacute (>7d). The chronic stage was omitted in this illustration. Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Overview of the measurement setting used in this study showing measurement times, blood samples, and volunteers. Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Individual time courses with mean (black solid line) and corresponding SD (shaded area) for T1, T2, and T2* for all subjects. Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Paired T1 and T2 time courses for all individuals ordered by visual inspection (from large T1 decrease to almost constant T1). A relationship between T1 and T2 evolution can be observed. Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Correlation of mean T2 values (0.5 · (initial plus minimum T2), T2,mean) with T2 difference (initial minus minimum T2, T2,diff) including the Pearson correlation coefficient (r), p-value, and regression formula. The regression line is given by a continuous line enclosed within the 95% confidence interval (shaded area). Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 Correlation of minimum T2 values (T2,min) with the decrease of T1 (T1,drop) including the Pearson correlation coefficient (r), p-value, and regression formula. The regression line is given by a continuous line enclosed within the 95% confidence interval (shaded area). Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 7 Correlation of level of deoxyHb (1−Y) with T2 difference (initial minus minimum T2, T2,diff) including the Pearson correlation coefficient (r), p-value, and regression formula. The regression line is given by a continuous line enclosed within the 95% confidence interval (shaded area). Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 8 Quadratic dependence of the initial R2 (R2,start) on the fraction of deoxyHb (1−Y). Forensic Science International 2016 262, 11-17DOI: (10.1016/j.forsciint.2016.02.032) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions