Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy Thereza Quirico-Santos,

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Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy Thereza Quirico-Santos, Isabella D'Andrea Meira, Aline C. Gomes, Valeria C. Pereira, Moises Pinto, Marisa Monteiro, Jorge M. Souza, Soniza V. Alves-Leon Journal of Neuroimmunology Volume 254, Issue 1, Pages 125-130 (January 2013) DOI: 10.1016/j.jneuroim.2012.08.004 Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 1 Comparison of cytokines in TLE patients and controls. Results are expressed as mean±SEM concentration of cytokines in the plasma from control subjects (n=42) and TLE patients (n=35) with extensive hippocampal atrophy and under treatment with anticonvulsant medication. Journal of Neuroimmunology 2013 254, 125-130DOI: (10.1016/j.jneuroim.2012.08.004) Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 2 Effect of surgery in plasma levels of inflammatory cytokines. OP (n=10) patients submitted to surgical resection of epileptogenic lesion by anterior temporal lobe resection and amygdalohippocampectomy and non-operated (nOP=25). Results are expressed as mean±SEM. Journal of Neuroimmunology 2013 254, 125-130DOI: (10.1016/j.jneuroim.2012.08.004) Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 3 Plasma levels of soluble p55 sTNFR1 and TNFα/TNFR1 ratio. (A) sTNFR plasma levels in control subjects (n=42) and TLE patients (n=35), unpaired two-tailed t-test showed significant difference p<0.021, and also F-test p<0.0001 comparing variances between groups; (B) TLE patients (OP n=10) submitted to surgical resection of epileptogenic lesion by anterior temporal lobe resection and non-operated (nOP) TLE patients (n=25), no difference (ns) between OP and nOP (p<0.05); (C) TNFα/TNFR ratio, the unpaired two-tailed t-test with Welch's correction showed significant difference between control and OP (p<0.0001) and nOP (p<0.009), and also between OP and nOP (p<0.020). Results are expressed as mean±SEM. Journal of Neuroimmunology 2013 254, 125-130DOI: (10.1016/j.jneuroim.2012.08.004) Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 4 TGF-β1 plasma levels in controls and TLE patients. TGFβ plasma levels in control subjects (n=42) and TLE patients (OP, n=10) submitted to surgical resection of epileptogenic lesion and non-operated (nOP) TLE patients (n=25). Two-tailed unpaired t-test with Welch's correction showed significant difference (p<0.0001) in plasma levels between control and TLE patients and Kruskal–Wallis test showed significant difference (p<0.001) between groups but no difference between nOP and OP (p<0.05). Results are expressed as mean±SEM. Journal of Neuroimmunology 2013 254, 125-130DOI: (10.1016/j.jneuroim.2012.08.004) Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 5 Plasma level of cytokines determined before and after surgery. Plasma level of cytokines determined 48h before (BS) and 8weeks after (AS) surgery paired t-test analysis showed a significant reduction of IL-1β (p=0.0063); IL-6 (p<0.0039); MIP-1α (p=0.0003); TNFα (p<0.0258) and sTNFR1 p55 (p<0.0381), but increased TGF-β1 (p<0.0149) levels 8weeks after surgery (AS). Results are expressed as mean±SEM. Journal of Neuroimmunology 2013 254, 125-130DOI: (10.1016/j.jneuroim.2012.08.004) Copyright © 2012 Elsevier B.V. Terms and Conditions