Animal model for Graves disease

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Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
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Animal model for Graves disease Animal model for Graves disease. This first animal model of Graves-like disease was achieved by injecting AKR/N mice with syngeneic (MHC-identical) fibroblasts dually transfected with mouse MHC class II (H2-k) and human TSH-R cDNA. About 25% of the animals developed endocrinologic (hyperthyroidism) and immunologic (TSI, TBII) features of Graves disease. Source: Endocrine Autoimmunity, Greenspan's Basic & Clinical Endocrinology, 10e Citation: Gardner DG, Shoback D. Greenspan's Basic & Clinical Endocrinology, 10e; 2017 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/2178/gardgreen10_ch02_f007-1.png&sec=166246987&BookID=2178&ChapterSecID=166246922&imagename= Accessed: October 23, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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