Catheter-related infection3

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Presentation transcript:

Catheter-related infection3 Supplementary File 12: Summary of reported complications from randomized trials fulfilling inclusion criteria. Study Hemodynamic Instability1 Bleeding2 Catheter-related infection3 Thrombocytopenia4 Arrhythmia5 Hypoglycemia6 IHD CRRT Simpson [33] na Kierdorf [26] John [30] 6/10 (60) 9/20 (45) 0/10 (0) 3/20 (15) Mehta [31] Gasparovic [29]§ 51/52 (98) 50/52 (96) Augustine [27] 16/40 (40) 5/40 (12.5) 2/40 (5) 0/40 (0) Uehlinger [34] Vinsonneau[45] 72 (39) 61 (35) 13 (7) 12 (7) 2 (1) 3 (2) 22 (12) 31 (18) 18 (10) 9 (5) 7 (4) Lins [46] Abbreviations: IHD = intermittent hemodialysis; CRRT = continuous renal replacement therapy; na = not available or specified. § In this study, a hypotensive episode during RRT was defined as a decrease in mean arterial pressure 10 mmHg. Overall, 512 episodes occurred in patients receiving CRRT and 619 in those receiving IHD (p=0.14).[29] 1. Hemodynamic instability was defined as a decrease in mean arterial pressure 10% from baseline or any hypotensive episode prompting an increase in the dose of vasopressor infusion or need for fluid bolus. 2. A bleeding episode was defined by need for intervention or transfusion. 3. A catheter-related infection was defined as objective evidence of infection prompting either catheter removal or therapy with antibiotics. 4. Thrombocytopenia was defined as absolute platelet count <50,000/uL during RRT. 5. An arrhythmia was defined a clinically important supraventricular or ventricular tachy/bradyarrhythmia prompting therapy. 6. Hypoglycemia was defined as an absolute serum glucose <3.0mmol/L or an value prompting intervention.