Volume 62, Issue 1, Pages (July 2012)

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Volume 62, Issue 1, Pages 78-84 (July 2012) A Novel Automated Platform for Quantifying the Extent of Skeletal Tumour Involvement in Prostate Cancer Patients Using the Bone Scan Index David Ulmert, Reza Kaboteh, Josef J. Fox, Caroline Savage, Michael J. Evans, Hans Lilja, Per-Anders Abrahamsson, Thomas Björk, Axel Gerdtsson, Anders Bjartell, Peter Gjertsson, Peter Höglund, Milan Lomsky, Mattias Ohlsson, Jens Richter, May Sadik, Michael J. Morris, Howard I. Scher, Karl Sjöstrand, Alice Yu, Madis Suurküla, Lars Edenbrandt, Steven M. Larson European Urology Volume 62, Issue 1, Pages 78-84 (July 2012) DOI: 10.1016/j.eururo.2012.01.037 Copyright © 2012 European Association of Urology Terms and Conditions

Fig. 1 Consolidated Standards of Reporting Trials diagram: participant flow of the study. MPP=Malmö Preventive Medicine Project; MCDS=Malmö Diet and Cancer Study; PCa=prostate cancer; BSI=Bone Scan Index. European Urology 2012 62, 78-84DOI: (10.1016/j.eururo.2012.01.037) Copyright © 2012 European Association of Urology Terms and Conditions

Fig. 2 Atlas based on 10 normal bone scans (a) with 12 skeletal regions (b) used for automated segmentation of the patient skeleton. European Urology 2012 62, 78-84DOI: (10.1016/j.eururo.2012.01.037) Copyright © 2012 European Association of Urology Terms and Conditions

Fig. 3 Patients from the evaluation group with automated Bone Scan Index (BSI) measurements of (a) 1.1, (b) 4.4, and (c) 12.8. The corresponding manual BSI measures were 1.2/1.0, 5.2/3.7, and 40.6/28.2, respectively. European Urology 2012 62, 78-84DOI: (10.1016/j.eururo.2012.01.037) Copyright © 2012 European Association of Urology Terms and Conditions

Fig. 4 Bland-Altman plot of manual and automated Bone Scan Index (BSI) readings. Two hundred thirty-four men had a negative (zero) score on manual and automated BSI (n=384). European Urology 2012 62, 78-84DOI: (10.1016/j.eururo.2012.01.037) Copyright © 2012 European Association of Urology Terms and Conditions

Fig. 5 Bland-Altman plot of two manual Bone Scan Index (BSI) readings. Fifty-one men had a negative (zero) score on manual and automated BSI (n=133). European Urology 2012 62, 78-84DOI: (10.1016/j.eururo.2012.01.037) Copyright © 2012 European Association of Urology Terms and Conditions

Fig. 6 Kaplan-Meier curve for death from prostate cancer among 384 men, stratified by automated Bone Scan Index (BSI) categories. European Urology 2012 62, 78-84DOI: (10.1016/j.eururo.2012.01.037) Copyright © 2012 European Association of Urology Terms and Conditions