Pulmonary Ground-Glass Opacity (GGO) Lesions–Large Size and a History of Lung Cancer are Risk Factors for Growth Miyako Hiramatsu, MD, Takuya Inagaki,

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Pulmonary Ground-Glass Opacity (GGO) Lesions–Large Size and a History of Lung Cancer are Risk Factors for Growth Miyako Hiramatsu, MD, Takuya Inagaki, MD, Tomoya Inagaki, MD, Yoshio Matsui, MD, Yukitoshi Satoh, MD, PhD, Sakae Okumura, MD, Yuichi Ishikawa, MD, PhD, Etsuo Miyaoka, PhD, Ken Nakagawa, MD Journal of Thoracic Oncology Volume 3, Issue 11, Pages 1245-1250 (November 2008) DOI: 10.1097/JTO.0b013e318189f526 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 A case showing GGO increase in size. (A) GGO in the left upper lobe, measuring 7 mm in diameter at detection. (B) Growth by 3 mm was confirmed after 10 months. Journal of Thoracic Oncology 2008 3, 1245-1250DOI: (10.1097/JTO.0b013e318189f526) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A case with GGO increase in size and formation of a solid part. (A) 9 mm and 7 mm GGOs detected in the left upper lobe. (B) Growth in size (to 17 and 12 mm, respectively) and became part-solid GGO after 7 months. Journal of Thoracic Oncology 2008 3, 1245-1250DOI: (10.1097/JTO.0b013e318189f526) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 The time to GGO growth curve for the 125 GGOs. The growth incidence at 5 years was estimated to be 30% in this study. Journal of Thoracic Oncology 2008 3, 1245-1250DOI: (10.1097/JTO.0b013e318189f526) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 The time to GGO growth curves according to initial size of GGO. The growth incidence for 10 mm or smaller (n = 87) and larger (n = 38) at 5 years were 14% and 66%, respectively. The difference between the curves was statistically significant (p < 0.01). Journal of Thoracic Oncology 2008 3, 1245-1250DOI: (10.1097/JTO.0b013e318189f526) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 5 The time to GGO growth curve was divided according to the initial size and a history of lung cancer. Fifty GGOs that were 10 mm or less in diameter and without a previous history of lung cancer did not grow within the follow-up period of 42 months. Journal of Thoracic Oncology 2008 3, 1245-1250DOI: (10.1097/JTO.0b013e318189f526) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions