Genomic Correlates of Atherosclerosis in Ancient Humans

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Presentation transcript:

Genomic Correlates of Atherosclerosis in Ancient Humans Albert Zink, L. Samuel Wann, Randall C. Thompson, Andreas Keller, Frank Maixner, Adel H. Allam, Caleb E. Finch, Bruno Frohlich, Hillard Kaplan, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Lucia Watson, Samantha L. Cox, Michael I. Miyamoto, Jagat Narula, Alexandre F.R. Stewart, Gregory S. Thomas, Johannes Krause Global Heart Volume 9, Issue 2, Pages 203-209 (June 2014) DOI: 10.1016/j.gheart.2014.03.2453 Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 1 The discovery site of the Iceman in the Ötztal Alps (South Tyrol, Italy). The glacier mummy was found in a 40-m–long, 2.5- to 3-m–deep and 5- to 8-m–wide rocky gully at the Tisenjoch, 3,210 m above sea level. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 2 The well-preserved mummy housed in the South Tyrolean Museum of Archeology in Bolzano, Italy. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 3 An automated refrigeration system is used for the conservation of the Iceman. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 4 Sampling of the Iceman for genetic analyses under sterile conditions. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 5 Three-dimensional CT reconstruction of the Iceman. The stone arrowhead is visible at the left shoulder region. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 6 Reconstruction of the Iceman. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions

Figure 7 Setup of the ancient DNA laboratory at the Institute for Mummies and the Iceman in Bolzano, Italy. Samples are processed in a specific 1-way workflow following strict rules to avoid any contamination. Global Heart 2014 9, 203-209DOI: (10.1016/j.gheart.2014.03.2453) Copyright © 2014 World Heart Federation (Geneva) Terms and Conditions