A case report of locally advanced triple negative breast cancer showing pathological complete response to weekly paclitaxel with bevacizumab treatment.

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A case report of locally advanced triple negative breast cancer showing pathological complete response to weekly paclitaxel with bevacizumab treatment following disease progression during anthracycline-based neoadjuvant chemotherapy Hideo Shigematsu, Shinji Ozaki, Daisuke Yasui, Taizo Hirata International Journal of Surgery Case Reports Volume 39, Pages 293-296 (January 2017) DOI: 10.1016/j.ijscr.2017.08.055 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Magnetic resonance imaging showed right breast mass with 3cm diameter in the upper outer portion of right breast and, multiple enlarged and fixed axillary lymph nodes with edematous change of surrounding soft tissue (A, B). Positron emission tomography computed tomography (PET-CT) showed right breast mass with SUVmax 19.73 and multiple axillary lymph node swelling with SUVmax range from 4.74 to 25.2 (C, D). International Journal of Surgery Case Reports 2017 39, 293-296DOI: (10.1016/j.ijscr.2017.08.055) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Computed tomography before NAC (A, B), after 2 cycles of EC (C, D), and after 4 cycles of weekly paclitaxel with bevacizumab (E, F). After 2 cycles of EC, progressive disease was recognized with 25% increment in the sum of breast tumor and axillary lymph node. Clinical complete response was recognized after completion of 4 cycles of weekly paclitaxel with bevacizumab (E, F). Last computed tomography was performed without contrast media because of patient allergic reaction. International Journal of Surgery Case Reports 2017 39, 293-296DOI: (10.1016/j.ijscr.2017.08.055) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Histological findings of the right breast (A) and axillary lymph nodes (B) (H&E stain X20). There was scarring with invasion of lymphocytes, histiocyte and multinucleated giant cell. No residual breast cancer cells were recognized showing a pathological complete response (Grade 3). International Journal of Surgery Case Reports 2017 39, 293-296DOI: (10.1016/j.ijscr.2017.08.055) Copyright © 2017 The Authors Terms and Conditions